Infection in systemic lupus erythematosus patients
| Autor: | Al Shimaa Khaled, Somaya Anwar, Dalia Dorgham |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty Cyclophosphamide SLE law.invention 03 medical and health sciences 0302 clinical medicine Rheumatology law Internal medicine medicine Disease activity 030212 general & internal medicine skin and connective tissue diseases 030203 arthritis & rheumatology medicine.diagnostic_test business.industry Early disease Damage index Mean age Intensive care unit Pathogenic organism Icu admission Hospitalization Male patient Erythrocyte sedimentation rate Infection lcsh:RC581-607 business medicine.drug |
| Zdroj: | Egyptian Rheumatologist, Vol 43, Iss 2, Pp 115-118 (2021) |
| ISSN: | 1110-1164 |
| DOI: | 10.1016/j.ejr.2020.12.007 |
| Popis: | Background: Infection is a leading cause of morbidity, mortality and hospital admission in systemic lupus erythematosus (SLE) patients. Aim of the work: To study infection in SLE patients regarding site of infection, pathogenic organism, hospitalization and/or intensive care unit (ICU) admission. Patients and methods: This study included 79 patients. SLE disease activity index (SLEDAI-2K) and damage index were evaluated. Detailed information about the site of infection and pathogens were reported. Results: 71 females and 8 male patients (F:M 8.9:1), with a mean age of 29 ± 9.6 years (17–55 years) and disease duration of 5.9 ± 5.7 years, 55 (69.6%) patients had infection at time of study while 24 (30.4%) did not. The SLEDAI-2 k and damage index were significantly higher in SLE patients with infection (14.2 ± 11.8 and 3.7 ± 3.7) compared to those without infection (5.9 ± 5.03 and 1.8 ± 1.3) (p = 0.03 and p = 0.045 respectively). Those with infection had a shorter disease duration (4.9 ± 5.2 vs 8.3 ± 6.2; p = 0.005), received more cyclophosphamide (56.4% vs 16.7%; p = 0.001), higher erythrocyte sedimentation rate (ESR) (75.5 ± 27.1 vs 35.8 ± 24.7 mm/1sthr) (p |
| Databáze: | OpenAIRE |
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