Differences in Clinical Features of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis in White and Asian Race
| Autor: | Heather E. Moss, Tanyatuth Padungkiatsagul, John J. Chen, Tetsuya Akaishi, Takayuki Takeshita, Panitha Jindahra, Toshiyuki Takahashi, Ichiro Nakashima |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual acuity Optic Neuritis genetic structures Visual Acuity Slit Lamp Microscopy White People Article Serology Myelin oligodendrocyte glycoprotein 03 medical and health sciences 0302 clinical medicine Asian People Median follow-up Recurrence Internal medicine medicine Demyelinating disease Eye Pain Humans Optic neuritis 030304 developmental biology Autoantibodies Retrospective Studies Aquaporin 4 0303 health sciences biology business.industry Retrospective cohort study Middle Aged medicine.disease Thailand United States Ophthalmology Immunoglobulin G 030221 ophthalmology & optometry Etiology biology.protein Female Myelin-Oligodendrocyte Glycoprotein medicine.symptom business |
| Zdroj: | Am J Ophthalmol |
| ISSN: | 1879-1891 |
| Popis: | PURPOSE: To determine whether clinical features and visual outcomes of myelin oligodendrocyte glycoprotein antibody-associated optic neuritis (MOG-ON) differ between subjects who are White compared with those who are Asian. DESIGN: Multicenter retrospective cohort. METHODS: Setting: Multicenter. Patient: 153 subjects who are White or Asian with history of adult-onset(age≥18years-old) optic neuritis and positive MOG-IgG serology by cell-based assay were enrolled from two unpublished cohorts(January 2017-November 2019) and nine published cohorts with case-level data available(2012-2018). Subjects with alternative etiologies of demyelinating disease and positive or lack of AQP-4-IgG serology result were excluded. Main outcome measures: Clinical features and final visual outcomes. RESULTS: One hundred and fifty-three subjects who are White(n=80) or Asian(n= 73) were included. 93(61%) were female, mean age of onset was 40.8±14.9 years-old, median follow up was 35.2(range1-432) months, which were all similar between White and Asian subjects. Subjects who are White were more likely to have recurrent optic neuritis(57(71%) vs. 20(27%);p=0.001) and extra-optic nerve manifestations(35(44%) vs. 8(11%);p=0.001). Optic disc swelling, neuroimaging findings, presenting visual acuity, treatment and final visual acuity did not differ according to subjects’ race. Despite the high prevalence of severe visual loss(20/40) at final examination(51(66%) of 77 subjects who are White vs. 52(74%) of 70 subjects who are Asian). CONCLUSION: Subjects with MOG-ON who are White were more likely to have recurrent disease and extra-optic nerve manifestations. Visual outcomes were similar between subjects who are White and those who are Asian. |
| Databáze: | OpenAIRE |
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