Factors correlated with peritoneal carcinomatosis and survival in patients with gastric cancer treated at a single institution in Brazil
| Autor: | Leila Maria M. P. de Melo, Celso Abdon Lopes de Melo, Ludmilla Thomé Domingos Chinen, Vladmir Cláudio Cordeiro de Lima, Milton Jose De Barros E. Silva, Solange Moraes Sanches, José Augusto Rinck, Andrea Paiva Gadelha Guimarães, Aldo Lourenço Abbade Dettino, Daniel Luiz Gimenes, Ulisses Ribaldo Nicolau, Tadeu Ferreira Paiva, Maria Nirvana Formiga, Edilson D. Pinheiro, Marcello Ferretti Fanelli, Marcelo Rocha Cruz |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Time Factors Antineoplastic Agents Kaplan-Meier Estimate Adenocarcinoma Risk Assessment Surgical oncology Gastrectomy Risk Factors Stomach Neoplasms Internal medicine medicine Odds Ratio Humans In patient Single institution Survival analysis Peritoneal Neoplasms Cause of death Neoplasm Staging Proportional Hazards Models Retrospective Studies business.industry Palliative Care Cancer Hematology General Medicine medicine.disease Peritoneal carcinomatosis Treatment Outcome Chemotherapy Adjuvant Surgery Female business Carcinoma Signet Ring Cell After treatment Brazil |
| Zdroj: | International journal of clinical oncology. 14(4) |
| ISSN: | 1437-7772 |
| Popis: | Gastric cancer is the second leading cause of death due to cancer worldwide and is particularly prevalent in Brazil. Promising new therapeutic agents have already shown activity in some gastrointestinal malignancies and their role in gastric cancer will need to be evaluated. Determining the prognostic factors of survival for patients with gastric cancer can help in identifying patients with a worse prognosis after treatment with the current chemotherapeutic regimens.A retrospective chart review of 186 patients diagnosed with gastric cancer and treated at a single institution in Brazil from January 1994 to December 2004 was carried out. Univariate and multivariate analyses were performed to identify patient- and tumor-related characteristics associated with peritoneal metastasis at diagnosis and with overall survival.Of the 186 patients, 76 were alive at the time of this analysis. The median survival for all patients was 30.1 months. Two independent factors associated with the presence of peritoneal metastasis at diagnosis were identified by multivariate analysis: signet-ring cell type (odds ratio [OR], 10.8; 95% confidence interval [CI], 3.1 to 37.5), and visceral metastasis (OR, 51.8; 95% CI, 12.4 to 215.4). The prognostic factors for poor survival were tumor stage T3 or T4 (hazard ratio [HR], 1.87; 95% CI, 1.09 to 3.22) and visceral metastasis (HR, 4.98; 95% CI, 3.02 to 8.20).Two factors correlated with peritoneal metastasis and two prognostic factors for survival were identified. These findings may contribute to clinical decision-making, treatment tailoring, and the design of future trials. |
| Databáze: | OpenAIRE |
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