Hyperamylasemia as an early predictor of mortality in patients with acute paraquat poisoning
| Autor: | Xigang Zhang, Jinghan Jiang, Liangfei Peng, Changbao Huang, Xiang Xue, Lina Bai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Medicine (General) Kaplan-Meier Estimate 030204 cardiovascular system & hematology medicine.disease_cause Biochemistry Gastroenterology chemistry.chemical_compound Leukocyte Count 0302 clinical medicine Paraquat oxidative stress pancreas prognostic factor Paraquat poisoning Alanine Transaminase General Medicine PARAQUAT POISONING Hospitalization medicine.anatomical_structure 030220 oncology & carcinogenesis Area Under Curve Creatinine Acute Disease Amylases Female Pancreas Adult medicine.medical_specialty Prognostic factor hyperamylasemia Elevated serum amylase 03 medical and health sciences R5-920 Internal medicine medicine Humans In patient Mortality Proportional Hazards Models business.industry Biochemistry (medical) Cell Biology Kinetics chemistry ROC Curve Multivariate Analysis Hyperamylasemia business Oxidative stress Retrospective Clinical Research Report |
| Zdroj: | Journal of International Medical Research, Vol 48 (2020) The Journal of International Medical Research |
| ISSN: | 1473-2300 |
| Popis: | Objective This study aimed to evaluate the relationship between elevated serum amylase levels and the prognosis of paraquat poisoning. Methods Patients were categorized into the elevated and non-elevated serum amylase groups according to serum amylase levels. Demographics, mortality, risk factors of elevated serum amylase levels, and injury to the pancreas were analyzed. Results A total of 457 patients were enrolled in this study and the overall mortality rate was 51.9%. Patients in the elevated group had worse indices than those in the non-elevated group. Kaplan–Meier survival analysis showed that the mortality rate in the elevated group was significantly higher than that in the non-elevated group (hazard ratio: 10.65, 95% confidence interval [CI]: 7.55–15.02). Multivariate Cox proportional hazards analysis showed that elevated serum amylase levels were related to mortality (hazard ratio: 2.066, 95% CI: 1.239–3.444). The receiver operating characteristic curve showed that the area under the curve was 0.724 (95% CI: 0.666–0.783) for serum amylase levels with 70.4% sensitivity and 74.0% specificity. Conclusion Elevated serum amylase levels are observed in PQ poisoning. This elevation might be one of the most accurate early prognostic factors for predicting severity and mortality. |
| Databáze: | OpenAIRE |
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