A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection
| Autor: | K. Eubanks, Merlin L. Robb, Jintana Intasan, Donn J Colby, Jerome H. Kim, John D. Kapson, H. Yang, James L. K. Fletcher, S. Tennakoon, Rv Study Teams, Michelle Chintanaphol, Ashanti Dantanarayana, Khuntalee Benjapornpong, Mark de Souza, Serena Spudich, Nicolas Chomont, Amélie Pagliuzza, Julie Mitchell, Robert J. Gorelick, Lydie Trautmann, Sharon R Lewin, Suteeraporn Pinyakorn, Frank Maldarelli, Nitiya Chomchey, Ajantha Rhodes, Eugene Kroon, Praphan Phanuphak, J Judy Chang, Nittaya Phanuphak, Jintanat Ananworanich |
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| Přispěvatelé: | Global Health, Graduate School, AII - Infectious diseases, APH - Aging & Later Life |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Epidemiology Immunology Microbiology law.invention Maraviroc 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Virology Internal medicine Medicine 030212 general & internal medicine Adverse effect Vorinostat Didanosine business.industry Acute HIV infection Original research Public Health Environmental and Occupational Health Latency reversal Neopterin Hydroxychloroquine QR1-502 Regimen 030104 developmental biology Infectious Diseases chemistry HIV remission Public aspects of medicine RA1-1270 business medicine.drug |
| Zdroj: | Journal of Virus Eradication Journal of Virus Eradication, Vol 6, Iss 3, Pp 100004-(2020) Journal of virus eradication, 6(3):100004. Mediscript Ltd |
| ISSN: | 2055-6640 |
| Popis: | Objective and Design: A randomized, open-label pilot study in individuals treated with antiretroviral therapy (ART) since acute HIV infection (AHI) with a regimen including a histone deacetylase inhibitor to induce HIV from latency and control HIV replication during subsequent treatment interruption (TI). Methods: Fifteen participants who initiated ART at AHI were randomized to vorinostat/hydroxychloroquine/maraviroc (VHM) plus ART (n = 10) or ART alone (n = 5). The VHM arm received three 14-day vorinostat cycles within 10 weeks before TI. ART was resumed for plasma viral load (VL) > 1,000 HIV RNA copies/mL. Primary outcome was proportion of participants on VHM + ART versus ART only with VL |
| Databáze: | OpenAIRE |
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