Analysis of Four Genes Involved in the Neurodevelopment Shows Association of rs4307059 Polymorphism in the Cadherin 9/10 Region with Completed Suicide
| Autor: | Izabela Chojnicka, Sylwia Fudalej, Grażyna Kostrzewa, Paweł Krajewski, Katarzyna Strawa, Marcin Wojnar, Marcin Fudalej, Rafał Płoski, Aleksandra Pawlak |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Genotype Cell Adhesion Molecules Neuronal Cadherin 9 Neurexin Poison control Nerve Tissue Proteins Single-nucleotide polymorphism Polymorphism Single Nucleotide Toxicology Gene Frequency Polymorphism (computer science) Humans Receptor trkB Medicine Genetic Predisposition to Disease Neural Cell Adhesion Molecules Gene Alleles Genetic Association Studies Biological Psychiatry Genetics Cadherin business.industry Brain-Derived Neurotrophic Factor Mental Disorders Calcium-Binding Proteins Middle Aged Cadherins Suicide Psychiatry and Mental health Neuropsychology and Physiological Psychology Case-Control Studies Female Poland business rs6265 |
| Zdroj: | Neuropsychobiology. 66:134-140 |
| ISSN: | 1423-0224 0302-282X |
| DOI: | 10.1159/000339559 |
| Popis: | Background: We hypothesized that DNA variants affecting neurodevelopment such as rs4307059 (CDH10/CDH9), rs930752 (NRXN1), rs6265 (BDNF) or rs10868235 (NTRK2) may predispose to completed suicide. Methodology: We used a case-control two-stage approach based on a discovery cohort (557 cases and ∼550 controls) and replication cohort (159 cases and 186 controls). The suicides were ascertained as consecutive cases autopsied at the Department of Forensic Medicine, Medical University of Warsaw, Poland. Results: In the discovery cohort we found an association between suicide and the CC genotype in the rs4307059 polymorphism (OR 1.64, p = 0.012). The trend for an overrepresentation of the CC homozygotes among suicides was replicated in the second cohort (OR 1.97, p = 0.056). Analysis in the pooled cohorts showed that rs4307059 CC was associated with completed suicide (OR 1.71, p = 0.002) also after Bonferroni correction (pcor. = 0.024). In an exploratory search for genotype-phenotype correlation we found that males with the rs4307059 CC genotype committed suicide earlier than those with CT/TT genotypes (p = 0.049). Conclusions: The CC genotype of rs4307059 located in the region between CDH9 and CDH10 is associated with completed suicide in a Polish cohort. |
| Databáze: | OpenAIRE |
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