Significant parameters in the evaluation of donor lungs in single-lung cellular ex vivo lung perfusion
| Autor: | Kenneth R. McCurry, Toshihiro Okamoto, Yoshifumi Itoda, Kamal S. Ayyat, J. Steven Hata, H. Niikawa |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Tissue and Organ Procurement Pulmonary Artery 030204 cardiovascular system & hematology pCO2 Pulmonary vein 03 medical and health sciences 0302 clinical medicine Single lung Internal medicine Pressure Humans Medicine Lung Tidal volume Bronchus business.industry Ex vivo lung perfusion Middle Aged respiratory system Tissue Donors respiratory tract diseases Donor lungs Perfusion medicine.anatomical_structure 030228 respiratory system Cardiology Female Surgery Cardiology and Cardiovascular Medicine business Lung Transplantation |
| Zdroj: | Interactive CardioVascular and Thoracic Surgery. 28:767-774 |
| ISSN: | 1569-9285 |
| DOI: | 10.1093/icvts/ivy327 |
| Popis: | OBJECTIVES Typically, single-lung ex vivo lung perfusion (SL-EVLP) is preferred when there is concern of contamination from the opposite lung. However, a comprehensive assessment of the SL-EVLP has not been completed. The purpose of this study is to compare the physiological parameters of SL-EVLP and double-lung EVLP (DL-EVLP) in the assessment of transplant suitability. METHODS Seven pairs of rejected donor lungs were perfused in cellular EVLP, with a tidal volume of 6 ml/kg ideal body weight and a perfusion flow of 70 ml/kg/min. The transplant suitability of each side was judged in the DL-EVLP. Subsequently, the tidal volume and flow were reduced by half. The right SL-EVLP was maintained for 10 min by clamping the left main pulmonary artery and the bronchus. Similarly, left SL-EVLP was performed. The physiological parameters were compared between SL-EVLP and DL-EVLP. RESULTS PO2/FiO2 ratio was significantly lower in SL-EVLP than in DL-EVLP [182.5 (127.5-309.5) vs 311.5 (257.5-377.0) mmHg, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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