Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA 4 and enzymatic conversion to the LTC 4 analogue
| Autor: | Simona Zarini, Saula Ravasi, Jean-Claude Rossi, Angelo Sala, Thierry Durand, Agnes Vidal, Jean-Pierre Vidal |
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| Rok vydání: | 2000 |
| Předmět: |
Blood Platelets
chemistry.chemical_classification Stereochemistry Leukotriene A4 Organic Chemistry Clinical Biochemistry Pharmaceutical Science Epoxide Substrate (chemistry) Biochemistry Chemical synthesis Leukotriene C4 chemistry.chemical_compound Enzyme chemistry Drug Discovery Organotin Compounds Humans Molecular Medicine Azide Aliphatic compound Molecular Biology Glutathione Transferase |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 10:665-668 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(00)00076-7 |
| Popis: | New photoaffinity probes based on C-19 position of leukotriene A4 has been synthesized from 19-hydroxy-LTA4 methyl ester. Enzymatic conversion into the LTC4 analogue yielded a potential tool for the study of cys-LT2 receptors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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