Integrative miRNA and whole-genome analyses of epicardial adipose tissue in patients with coronary atherosclerosis
| Autor: | Marica Cariello, Simona D'Amore, Antonio Tamburro, Antonio Moschetta, Andria D'Orazio, Francesco Dimitri Petridis, Marco Di Eusanio, Roberto Di Bartolomeo, Carlo Sabbà, David Rutigliano, Fabio Pellegrini, Gianluca Folesani, Giuseppe Palasciano, Michele Vacca, Giusi Graziano, Lorena Salvatore |
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| Přispěvatelé: | Vacca, Michele, DI EUSANIO, Marco, Cariello, Marica, Graziano, Giusi, D'Amore, Simona, Petridis, FRANCESCO DIMITRI, D'Orazio, Andria, Salvatore, Lorena, Tamburro, Antonio, Folesani, Gianluca, Rutigliano, David, Pellegrini, Fabio, Sabbà, Carlo, Palasciano, Giuseppe, DI BARTOLOMEO, Roberto, Moschetta, Antonio |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Chemokine Physiology Adipose tissue Inflammation 030204 cardiovascular system & hematology Biology Bioinformatics 03 medical and health sciences 0302 clinical medicine Physiology (medical) Epicardial adipose tissue microRNA medicine Humans Genetic Predisposition to Disease CCL13 Coronary atherosclerosis miRNA Aged Aged 80 and over Regulation of gene expression Genome Human MicroRNA Lipid metabolism Middle Aged Atherosclerosis Lipid Metabolism Metabolic syndrome MicroRNAs 030104 developmental biology Adipose Tissue Gene Expression Regulation Nuclear receptor Atherosclerosi biology.protein Gene expression Chemokines medicine.symptom Cardiology and Cardiovascular Medicine Human Genome-Wide Association Study |
| Zdroj: | Cardiovascular Research. 109:228-239 |
| ISSN: | 1755-3245 0008-6363 |
| DOI: | 10.1093/cvr/cvv266 |
| Popis: | Background Epicardial adipose tissue (EAT) is an atypical fat depot surrounding the heart with a putative role in the development of atherosclerosis. Methods and results We profiled genes and miRNAs in perivascular EAT and subcutaneous adipose tissue (SAT) of metabolically healthy patients without coronary artery disease (CAD) vs. metabolic patients with CAD. Compared with SAT, a specific tuning of miRNAs and genes points to EAT as a tissue characterized by a metabolically active and pro-inflammatory profile. Then, we depicted both miRNA and gene signatures of EAT in CAD, featuring a down-regulation of genes involved in lipid metabolism, mitochondrial function, nuclear receptor transcriptional activity, and an up-regulation of those involved in antigen presentation, chemokine signalling, and inflammation. Finally, we identified miR-103-3p as candidate modulator of CCL13 in EAT, and a potential biomarker role for the chemokine CCL13 in CAD. Conclusion EAT in CAD is characterized by changes in the regulation of metabolism and inflammation with miR-103-3p/CCL13 pair as novel putative actors in EAT function and CAD. |
| Databáze: | OpenAIRE |
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