Prospective Plant Based Anticancer Lead Molecules
| Autor: | Prabhjot Kaur, Vikas Sharma |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Biological Products
Molecular Structure Plant based General Medicine Computational biology Biology Antineoplastic Agents Phytogenic 01 natural sciences 0104 chemical sciences Structure-Activity Relationship 010404 medicinal & biomolecular chemistry Lead (geology) Neoplasms Drug Discovery Animals Humans Cell Proliferation |
| Zdroj: | Current Topics in Medicinal Chemistry. 18:2567-2583 |
| ISSN: | 1568-0266 |
| Popis: | Nature has been a source of a wide range of products being utilized for the treatment of various diseases like malaria, cancer, diabetes etc. Among these, cancer is emerging as a leading cause of deaths worldwide and the development of cross-resistance to already established drugs increases the need for novel anticancer drugs. To discover novel anticancer molecules, it is a necessity to unearth the molecules which can act as anticancer agents. Taking natural products in vision, phytoconstituents like terpenoids, flavones, glycosides and alkaloids might act as a major source of lead molecules. Considering the anticancer prospectives of phytoconstituents, different unknown lead molecules are summarized in this review. The present review highlights the representative studies of plant-based anticancer agents which are classified as per their phytochemical nature. Furthermore, important key points along with important structure-activity relationships points regarding selected lead molecules are also discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|