System analysis of the regulation of the immune response by CD147 and FOXC1 in cancer cell lines
| Autor: | Ding Wei, Can Li, Zi Ling Wang, Jing Xu, Ze-Kun Liu, Ling-Min Kong, Zhi-Nan Chen, Yu-Kui Shang, Huijie Bian |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Regulator Biology immune response Transmembrane protein Cell biology Extracellular matrix 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Oncology Cell culture 030220 oncology & carcinogenesis Cancer cell Gene expression CD147 gene expression FOXC1 cancer cell line encyclopedia Gene Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | CD147, encoded by BSG, is a highly glycosylated transmembrane protein that belongs to the immunological superfamily and expressed on the surface of many types of cancer cells. While CD147 is best known as a potent inducer of extracellular matrix metalloproteinases, it can also function as a key mediator of inflammatory and immune responses. To systematically elucidate the function of CD147 in cancer cells, we performed an analysis of genome-wide profiling across the Cancer Cell Line Encyclopedia (CCLE). We showed that CD147 mRNA expression was much higher than that of most other genes in cancer cell lines. CD147 varied widely across these cell lines, with the highest levels in the ovary (COLO704) and stomach (SNU668), intermediate levels in the lung (RERFLCKJ, NCIH596 and NCIH1651) and lowest levels in hematopoietic and lymphoid tissue (UT7, HEL9217, HEL and MHHCALL3) and the kidney (A704 and SLR20). Genome-wide analyses showed that CD147 expression was significantly negatively correlated with immune-related genes. Our findings implicated CD147 as a novel regulator of immune-related genes and suggest its important role as a master regulator of immune-related responses in cancer cell lines. We also found a high correlation between the expression of CD147 and FOXC1, and proved that CD147 was a direct transcriptional target of FOXC1. Our findings demonstrate that FOXC1 is a novel regulator of CD147 and confirms its role as a master regulator of the immune response. |
| Databáze: | OpenAIRE |
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