Adipokines and C-reactive protein as indicators of MetS presence in obese Greek children: The Healthy Growth Study

Autor: Eva Karaglani, Argiris Theodosiou, Yannis Manios, Emilia Vassilopoulou, Emmanouela Giannopoulou, George Moschonis
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_specialty
HDL-C
High-density Lipoprotein Cholesterol
Health
Toxicology and Mutagenesis
Population
Adipokine
IR
Insulin Resistance
Overweight
Toxicology
Childhood obesity
BP
Arterial Blood Pressure
C-reactive protein
CVD
Cardiovascular disease
DPB
Diastolic Blood Pressure
Adipokines
RA1190-1270
Internal medicine
medicine
MetS
Metabolic Syndrome
education
Uncategorized
ComputingMethodologies_COMPUTERGRAPHICS
education.field_of_study
TC
Total Cholesterol
Adiponectin
business.industry
WC
Waist Circumference
TG
Triglycerides
Anthropometry
medicine.disease
Obesity
Paving the Future of Neurology: Advancements in Genetics
Epigenetics
Environmental Exposures
Pathophysiology
Biomarkers
Management and Links to COVID-19 of Neurological Disorder
Metabolic syndrome
SBP
Systolic Blood Pressure
DM
Diabetes Mellitus
Toxicology. Poisons
CRP
C-reactive protein
HGS
Healthy Growth Study
medicine.symptom
LDL-C
Low-density Lipoprotein Cholesterol
business
Zdroj: Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 1645-1650 (2021)
ISSN: 2214-7500
Popis: Graphical abstract
Highlights • MetS occurs in a 1 out of 4 obese children and increases the future risk of serious health complications. • The serum level of adiponectin decreases while leptin increases as body weight increases, in the understudy children group. • The serum level of the inflammatory marker CRP increases significantly as body weight increases in the understudy population. • Adipokines and CRP can distinguish the children with Metabolic Syndrome as compared to children with no Metabolic Syndrome.
Background Metabolic syndrome (MetS) occurs in a proportion of overweight and obese children and increases their future risk of serious health complications, even in adolescence and young adulthood. We aimed to explore the role of certain adipokines and inflammatory markers in identifying children with MetS. Methods This study is a secondary analysis of data coming from the Healthy Growth Study, a cross-sectional study conducted with schoolchildren in Greece. The present study included data from a representative sample of 1376 schoolchildren (mean age: 11.19 ± 0.66 years), recruited from 77 primary schools in four large regions in Greece. Anthropometric, clinical and biochemical data were recorded. Children’s body weight status and the presence of MetS were determined and their correlation with the serum levels of leptin, adiponectin and C-reactive protein (CRP) was explored. Results The prevalence of the MetS was 21.7 % and 3.7 % in obese and overweight children, respectively. The balance of adipokines was disturbed in obesity, as the serum level of adiponectin decreased as body weight increased, while the serum level of leptin increased. The serum level of the inflammatory marker CRP increased significantly as body weight increased. Discriminant analysis showed that these factors could distinguish the children with MetS as compared to children with no MetS. Conclusions In the under study Mediterranean childhood population, monitoring of the levels of adipokines and CRP could identify the overweight and obese children with MetS. Appropriate individualized dietary and lifestyle interventions can be applied in these children to prevent health complications associated with MetS.
Databáze: OpenAIRE
Externí odkaz: