Electroencephalographic patterns during sleep in children with chromosome 15q11.2-13.1 duplications (Dup15q)
| Autor: | Dimitrios Arkilo, Kadi Luchsinger, Susana Boronat, Basanagoud Mudigoudar, Ronald L. Thibert, Melanie Jennesson, Kenneth C. Sassower, Okeanis Vaou, Shafali S. Jeste, Orrin Devinsky, Jason T. Lerner |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Dup15q syndrome Chromosome Disorders Electroencephalography Audiology EEG patterns Behavioral Neuroscience Epilepsy 0302 clinical medicine Child Children medicine.diagnostic_test Neurology Anesthesia Child Preschool Female medicine.symptom Psychology Developmental regression Human medicine.medical_specialty Adolescent Clinical Sciences Status epilepticus Dup15q Chromosomes 03 medical and health sciences Seizures medicine Humans Ictal Preschool Retrospective Studies Chromosome Aberrations Chromosomes Human Pair 15 Neurology & Neurosurgery Pair 15 medicine.disease 030104 developmental biology Mood disorders Delta Rhythm Neurodevelopmental Disorders Neurology (clinical) Sleep 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Arkilo, D; Devinsky, O; Mudigoudar, B; Boronat, S; Jennesson, M; Sassower, K; et al.(2016). Electroencephalographic patterns during sleep in children with chromosome 15q11.2-13.1 duplications (Dup15q). EPILEPSY & BEHAVIOR, 57, 133-136. doi: 10.1016/j.yebeh.2016.02.010. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7bj8d88p Epilepsy & behavior : E&B, vol 57, iss Pt A |
| DOI: | 10.1016/j.yebeh.2016.02.010. |
| Popis: | Our objective was to define the EEG features during sleep of children with neurodevelopmental disorders due to copy number gains of 15q11-q13 (Dup15q). We retrospectively reviewed continuous EEG recordings of 42 children with Dup15q (mean age: eight years, 32 with idic15), and data collected included background activity, interictal epileptiform discharges, sleep organization, and ictal activity. Three patterns were recognized: Pattern 1: Alpha–delta sleep was noted in 14 children (33%), not associated with any clinical changes. Pattern 2: Electrical status epilepticus in sleep was noted in 15 children (35%), all diagnosed with treatmentresistant epilepsy. Thirteen of the 15 children had clinical seizures. Pattern 3: Frequent bursts of high amplitude bifrontal predominant, paroxysmal fast activity (12–15 Hz) during non-REM sleep was noted in 15 children (35%). All 15 children had treatment-resistant epilepsy. This is the first report of electroencephalographic patterns during sleep of children with Dup15q reporting alpha-delta rhythms, CSWS, and high amplitude fast frequencies. Alpha-delta rhythms are described in children with dysautonomia and/or mood disorders and CSWS in children with developmental regression. The significance of these findings in cognitive function and epilepsy for the children in our cohort needs to be determined with follow-up studies. |
| Databáze: | OpenAIRE |
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