Metabolaid® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation

Autor: Nuria Caturla, Yang-Chun Park, Young-Cheol Lee, Jonathan Jones, Bokkee Min, Won-Kyung Yang, Seung-Hyung Kim, Young-Sil Lee, Hwa Yeon Kim
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
obesity
AMP-activated kinase
White adipose tissue
AMP-Activated Protein Kinases
Weight Gain
lemon verbena
0302 clinical medicine
AMP-activated protein kinase
hyperlipidemia
Adiposity
2. Zero hunger
Nutrition and Dietetics
biology
Leptin
Hibiscus sabdariffa
Verbena
thermogenesis
hibiscus
3. Good health
030220 oncology & carcinogenesis
lcsh:Nutrition. Foods and food supply
Signal Transduction
medicine.medical_specialty
Adipose Tissue
White
Enzyme Activators
lcsh:TX341-641
Flowers
Diet
High-Fat
Article
adipogenesis
03 medical and health sciences
Internal medicine
Diabetes mellitus
medicine
Animals
Adiponectin
Plant Extracts
business.industry
medicine.disease
biology.organism_classification
Enzyme Activation
Mice
Inbred C57BL
Plant Leaves
Disease Models
Animal
030104 developmental biology
Endocrinology
biology.protein
Anti-Obesity Agents
business
Lippia
Thermogenesis
Biomarkers
Lemon verbena
Food Science
Zdroj: Nutrients, Vol 10, Iss 9, p 1204 (2018)
Nutrients
Volume 10
Issue 9
ISSN: 2072-6643
Popis: Lemon verbena (Lippia citriodora) has been used as a food spice, cosmetic, and in traditional medicine formulations to treat asthma and diabetes in South America and Southern Europe. Hibiscus flower (Hibiscus sabdariffa L.) is used in traditional Chinese medicine in the form of a tea to treat hypertension and inflammation. In the present study, we examined the synergistic effects of a formula of Metabolaid®
(MetA), a combination of lemon verbena and hibiscus-flower extracts, on obesity and its complications in high-fat-diet (HFD)-induced obese mice. The results showed that MetA decreased body weight, white adipose tissue (WAT), and liver weight. Additionally, serum and hepatic lipid profiles, glucose levels, glucose tolerance, and cold-induced thermogenesis were significantly improved. Appetite-regulating hormones adiponectin and leptin were significantly increased and decreased, respectively, while the inflammatory-related factors tumor necrosis factor (TNF)-&alpha
and interleukin (IL)-6 were downregulated by MetA. Adipogenesis-activating gene expression was decreased, while increased thermogenesis-inducing genes were upregulated in the WAT, correlating with increased phosphorylation of AMPK and fatty-acid oxidation in the liver. Taken together, these results suggest that MetA decreased obesity and its complications in HFD mice. Therefore, this formula may be a candidate for the prevention and treatment of obesity and its complications.
Databáze: OpenAIRE
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