Morphine Enhances HIV Infection of Neonatal Macrophages
| Autor: | Jeffrey D. Merrill, Kathy Mooney, Li Song, Wen-Zhe Ho, Yuan Li, Rashmin C. Savani, Steven D. Douglas, Chang-Jiang Guo, David S. Metzger, Xu Wang |
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| Rok vydání: | 2003 |
| Předmět: |
Receptors
CCR5 Chemokine receptor CCR5 medicine.drug_class Gene Expression HIV Infections Article Naltrexone Immune system Acquired immunodeficiency syndrome (AIDS) Opioid receptor Immunopathology medicine Humans Chemokine CCL4 Cells Cultured Morphine biology Transmission (medicine) business.industry Macrophages Infant Newborn virus diseases Macrophage Inflammatory Proteins medicine.disease Infectious Disease Transmission Vertical Analgesics Opioid Pediatrics Perinatology and Child Health Immunology biology.protein business medicine.drug |
| Zdroj: | Pediatric Research. 54:282-288 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/01.pdr.0000074973.83826.4c |
| Popis: | Perinatal transmission of HIV accounts for almost all new HIV infections in children. There is an increased risk of perinatal transmission of HIV with maternal illicit substance abuse. Little is known about neonatal immune system alteration and subsequent susceptibility to HIV infection after morphine exposure. We investigated the effects of morphine on HIV infection of neonatal monocyte-derived macrophages (MDM). Morphine significantly enhanced HIV infection of neonatal MDM. Morphine-induced HIV replication in neonatal MDM was completely suppressed by naltrexone, the opioid receptor antagonist. Morphine significantly up-regulated CCR5 receptor expression and inhibited the endogenous production of macrophage inflammatory protein-1beta in neonatal MDM. Thus, morphine, most likely through alteration of beta-chemokines and CCR5 receptor expression, enhances the susceptibility of neonatal MDM to HIV infection, and may have a cofactor role in perinatal HIV transmission and infection. |
| Databáze: | OpenAIRE |
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