Cationic, amphiphilic dextran nanomicellar clusters as an excipient for dry powder inhaler formulation
| Autor: | G. S. Vinod Kumar, Chandrasekharan C Kartha, Mithun Varghese Vadakkan, S. S. Binil Raj |
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| Rok vydání: | 2015 |
| Předmět: |
Materials science
Drug Compounding Biomedical Engineering Excipient Pharmaceutical formulation Biochemistry Biomaterials Diffusion Excipients Rats Sprague-Dawley chemistry.chemical_compound Surface-Active Agents Nanocapsules In vivo Cations Amphiphile Administration Inhalation medicine Organic chemistry Animals Desiccation Molecular Biology Antibiotics Antitubercular Micelles Chromatography Dextrans Dry Powder Inhalers General Medicine Dry-powder inhaler Rats Dextran chemistry Spray drying Toxicity Powders Rifampin Biotechnology medicine.drug |
| Zdroj: | Acta biomaterialia. 23 |
| ISSN: | 1878-7568 |
| Popis: | Effective delivery of drugs to alveoli in a controlled manner using hydrophobic polymers as carriers has already been reported. Preclinical studies revealed that toxicity and hydrophobicity are related to each other in pulmonary delivery. Here, we are reporting a chemically modified dextran having amphiphilicity and cationicity achieved by controlled grafting of stearyl amine. Two proportions of lipopolymers were synthesized and physico-chemical characterization was carried out. In vivo evaluation of sub-acute toxicity of the synthesized lipopolymer in Sprague–Dawley rats was carried out for three months. This was followed by a histological evaluation of the sacrificed animal’s lung. Further, the synthesized lipopolymer was formulated with drug (Rifampicin) loaded inhalable microparticles through spray drying. The final drug formulation was tested for toxicity and proinflammatory responses in human cell lines. Dose deposition efficiency of the formulation was determined using Anderson Cascade Impactor. |
| Databáze: | OpenAIRE |
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