Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder
| Autor: | Michael G. McCusker, Barbara W. Schweizer, Oscar J. Bienvenu, Francis M. Mondimore, James B. Potash, Fernando S. Goes, J. R. DePaulo, Dean F. MacKinnon |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Comorbidity Severity of Illness Index behavioral disciplines and activities Article Specific phobia Prevalence of mental disorders Interview Psychological mental disorders medicine Humans Genetic Predisposition to Disease Bipolar disorder Psychiatry Applied Psychology Depressive Disorder Major Models Statistical Panic disorder Panic medicine.disease Anxiety Disorders Pedigree Psychiatry and Mental health Mood disorders Multivariate Analysis Anxiety Major depressive disorder Female medicine.symptom Psychology Clinical psychology |
| Zdroj: | Psychological Medicine. 42:1449-1459 |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/s0033291711002637 |
| Popis: | BackgroundCo-morbidity of mood and anxiety disorders is common and often associated with greater illness severity. This study investigates clinical correlates and familiality of four anxiety disorders in a large sample of bipolar disorder (BP) and major depressive disorder (MDD) pedigrees.MethodThe sample comprised 566 BP families with 1416 affected subjects and 675 MDD families with 1726 affected subjects. Clinical characteristics and familiality of panic disorder, social phobia, specific phobia and obsessive-compulsive disorder (OCD) were examined in BP and MDD pedigrees with multivariate modeling using generalized estimating equations.ResultsCo-morbidity between mood and anxiety disorders was associated with several markers of clinical severity, including earlier age of onset, greater number of depressive episodes and higher prevalence of attempted suicide, when compared with mood disorder without co-morbid anxiety. Familial aggregation was found with co-morbid panic and OCD in both BP and MDD pedigrees. Specific phobia showed familial aggregation in both MDD and BP families, although the findings in BP were just short of statistical significance after adjusting for other anxiety co-morbidities. We found no evidence for familiality of social phobia.ConclusionsOur findings suggest that co-morbidity of MDD and BP with specific anxiety disorders (OCD, panic disorder and specific phobia) is at least partly due to familial factors, which may be of relevance to both phenotypic and genetic studies of co-morbidity. |
| Databáze: | OpenAIRE |
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