Microbial and nutritional influence on endocrine control of growth
| Autor: | Filipe De Vadder, François Leulier, Amélie Joly |
|---|---|
| Přispěvatelé: | Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR-18-CE15-0011,SymEnvLop,Symbiose bénéfique hôte-microbiote durant une sous nutrition chronique: Enveloppe bactérienne et promotion de la croissance linéaire(2018), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Somatotropic cell [SDV]Life Sciences [q-bio] Physiology Nutritional Status 030209 endocrinology & metabolism Endocrine System Gut flora digestive system Longitudinal bone growth 03 medical and health sciences Paracrine signalling 0302 clinical medicine Endocrinology medicine Endocrine system Animals Humans Microbiome Insulin-Like Growth Factor I Endocrine control Molecular Biology 2. Zero hunger biology biology.organism_classification medicine.disease Gastrointestinal Microbiome Malnutrition 030104 developmental biology Growth Hormone Growth and Development |
| Zdroj: | Journal of Molecular Endocrinology Journal of Molecular Endocrinology, 2021, 66 (3), pp.R67-R73. ⟨10.1530/JME-20-0288⟩ Journal of Molecular Endocrinology, BioScientifica, 2021, 66 (3), pp.R67-R73. ⟨10.1530/JME-20-0288⟩ |
| ISSN: | 0952-5041 1479-6813 |
| Popis: | International audience; The worrying number of children suffering from undernutrition and consequent stunting worldwide makes the understanding of the relationship between nutritional status and postnatal growth crucial. Moreover, it is now well established that undernourished children harbor an altered microbiota, correlating with impaired growth. In this review, we describe how murine models have been used to explore the functional relationships between endocrine regulation of growth, nutrition and gut microbiota. In numerous Mammalian species, postnatal growth is mainly regulated by the conserved GH/IGF1 somatotropic axis that acts through endocrine and paracrine pathways, notably enabling longitudinal bone growth. Recent studies have demonstrated that the microbiota effects on growth could involve a modulation of GH and IGF1 circulating levels. Besides, the GH/IGF1 somatotropic axis may regulate the gut microbiota composition and diversity. Studying the bidirectional relationship between growth hormones and the gut microbiome could therefore help developing microbiota-targeting therapies in order to reduce the long-term consequences of stunting. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|