Buprenorphine: Far Beyond the 'Ceiling'
| Autor: | Consalvo Mattia, Sabatino Maione, Antonio Luigi Pastore, Pamela Locarini, Livio Luongo, Rosmara Infantino |
|---|---|
| Přispěvatelé: | Infantino, Rosmara, Mattia, Consalvo, Locarini, Pamela, Luigi Pastore, Antonio, Maione, Sabatino, Luongo, Livio |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Opinion medicine.medical_specialty media_common.quotation_subject Analgesic Disease biased agonist protean agonist Microbiology Biochemistry 03 medical and health sciences 0302 clinical medicine medicine Humans Intensive care medicine Molecular Biology media_common Analgesics business.industry Addiction Chronic pain medicine.disease buprenorphine QR1-502 Substance abuse chronic pain 030104 developmental biology Third line Neuropathic pain Quality of Life Neuralgia business 030217 neurology & neurosurgery Buprenorphine medicine.drug |
| Zdroj: | Biomolecules Biomolecules, Vol 11, Iss 816, p 816 (2021) |
| Popis: | Chronic pain, including neuropathic pain, represents an untreated disease with important repercussions on the quality of life and huge costs on the national health system. It is well known that opioids are the most powerful analgesic drugs, but they represent the second or third line in neuropathic pain, that remain difficult to manage. Moreover, these drugs show several side effects that limit their use. In addition, opioids possess addictive properties that are associated with misuse and drug abuse. Among available opioids compounds, buprenorphine has been suggested advantageous for a series of clinical reasons, including the effectiveness in neuropathic pain. Some properties are partly explained by its unique pharmacological characteristics. However, questions on the dynamic profile remain to be answered. Pharmacokinetics optimization strategies, and additional potentialities, are still to be explored. In this paper, we attempt to conceptualize the potential undiscovered dynamic profile of buprenorphine. |
| Databáze: | OpenAIRE |
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