Transplantation for cholangiocarcinoma: when and for whom?
| Autor: | David J. Rea, Gregory J. Gores, Charles B. Rosen, Julie K. Heimbach, David M. Nagorney |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Chemotherapy business.industry medicine.medical_treatment General surgery Patient survival Liver transplantation Out patients Liver Transplantation Transplantation Cholangiocarcinoma surgical procedures operative medicine.anatomical_structure Bile Ducts Intrahepatic Oncology Bile Duct Neoplasms Palliative radiation medicine Humans Surgery Radiology business Lymph node Contraindication |
| Zdroj: | Surgical oncology clinics of North America. 18(2) |
| ISSN: | 1055-3207 |
| Popis: | Liver transplantation for cholangiocarcinoma has historically been maligned. Because of a high recurrence rate and poor patient survival, the disease has been viewed as an absolute contraindication to transplantation. Based on good results using neoadjuvant and palliative radiation, a protocol for liver transplantation in selected patients with unresectable hilar cholangiocarcinoma was developed in 1993. Neoadjuvant radiation is followed by operative staging to rule out patients with lymph node metastases before liver transplantation. This approach has achieved results superior to standard surgical therapy, with 72% 5-year survival for patients with unresectable disease. |
| Databáze: | OpenAIRE |
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