Onyx®in the management of cranial arteriovenous malformations
| Autor: | Jalal Jalaly, Shaker A. Mousa, John C Dalfino |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Intracranial Arteriovenous Malformations
medicine.medical_specialty Rupture Spontaneous business.industry Biomedical Engineering Treatment options Arteriovenous malformation General Medicine Enbucrilate medicine.disease Surgery Embolic Agent Ethylene vinyl alcohol copolymer Embolism Stroke prevention Humans Medicine Dimethyl Sulfoxide Polyvinyls business |
| Zdroj: | Expert Review of Medical Devices. 10:453-459 |
| ISSN: | 1745-2422 1743-4440 |
| Popis: | The ethylene vinyl alcohol copolymer, Onyx® (ev3, Inc., MN, USA), is an embolic agent used in the management of arteriovenous malformations (AVMs) and was approved by the US FDA in 2005. Use of Onyx has resulted in higher curative rates compared with previous embolic agents such as N-butyl-2-cyanoacrylate. Onyx has several advantages over previous embolic agents. For instance, Onyx is a copolymer and does not adhere to catheters but solidifies slowly owing to the diffusion of its solvent dimethyl sulfoxide. This review focuses on different results obtained from the experience of different neurointerventionalists with an emphasis on the aim to cure. The studies presented are compared in terms of curative rates, morbidity and mortality. Ideas are presented for future treatment options for AVM rupture using nanotargeted therapy with the guide of specific markers highly expressed on the surface of cells or tissues of interest. Such nanotargeted therapy might transform AVM treatment with new embolic agents. |
| Databáze: | OpenAIRE |
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