Clinical severity of rhinovirus/enterovirus compared to other respiratory viruses in children
Autor: | Dominik Mertz, Jemila S. Hamid, Sandra A. Asner, Marek Smieja, Astrid Petrich, Susan E. Richardson |
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Rok vydání: | 2014 |
Předmět: |
Male
Pulmonary and Respiratory Medicine Critical Care Epidemiology respiratory syncytial virus viruses Influenza (flu) Clinical disease severity single viral infections medicine.disease_cause human rhinovirus/enterovirus stomatognathic system Community-acquired pneumonia otorhinolaryngologic diseases medicine Humans Clinical severity Respiratory system Child Respiratory Tract Infections Retrospective Studies business.industry Infant Newborn Public Health Environmental and Occupational Health Infant virus diseases Original Articles Length of Stay medicine.disease Virology respiratory tract diseases Hospitalization Infectious Diseases Respiratory syncytial virus (RSV) Virus Diseases Infectious disease (medical specialty) Child Preschool Viruses Immunology Enterovirus Female Rhinovirus influenza business |
Zdroj: | Influenza and Other Respiratory Viruses |
ISSN: | 1750-2659 1750-2640 |
Popis: | Background Human rhinovirus/enterovirus (HRV/ENT) infections are commonly identified in children with acute respiratory infections (ARIs), but data on their clinical severity remain limited. Objectives We compared the clinical severity of HRV/ENT to respiratory syncytial virus (RSV), influenza A/B (FLU), and other common respiratory viruses in children. Patients/Methods Retrospective study of children with ARIs and confirmed single positive viral infections on mid-turbinate swabs by molecular assays. Outcome measures included hospital admission and, for inpatients, a composite endpoint consisting of intensive care admission, hospitalization >5 days, oxygen requirements or death. Results A total of 116 HRV/ENT, 102 RSV, 99 FLU, and 64 other common respiratory viruses were identified. Children with single HRV/ENT infections presented with significantly higher rates of underlying immunosuppressive conditions compared to those with RSV (37·9% versus 13·6%; P < 0·001), FLU (37·9% versus 22%; P = 0·018) or any other single viral infection (37·9% versus 22·5%; P = 0·024). In multivariable analysis adjusted for underlying conditions and age, children with HRV/ENT infections had increased odds of hospitalization compared to children with RSV infections (OR 2·6; 95% CI 1·4, 4·8; P < 0·003) or FLU infections (OR 3·0; 95% CI 1·6, 5·8 |
Databáze: | OpenAIRE |
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