Clinical severity of rhinovirus/enterovirus compared to other respiratory viruses in children

Autor: Dominik Mertz, Jemila S. Hamid, Sandra A. Asner, Marek Smieja, Astrid Petrich, Susan E. Richardson
Rok vydání: 2014
Předmět:
Male
Pulmonary and Respiratory Medicine
Critical Care
Epidemiology
respiratory syncytial virus
viruses
Influenza (flu)
Clinical disease severity
single viral infections
medicine.disease_cause
human rhinovirus/enterovirus
stomatognathic system
Community-acquired pneumonia
otorhinolaryngologic diseases
medicine
Humans
Clinical severity
Respiratory system
Child
Respiratory Tract Infections
Retrospective Studies
business.industry
Infant
Newborn
Public Health
Environmental and Occupational Health
Infant
virus diseases
Original Articles
Length of Stay
medicine.disease
Virology
respiratory tract diseases
Hospitalization
Infectious Diseases
Respiratory syncytial virus (RSV)
Virus Diseases
Infectious disease (medical specialty)
Child
Preschool
Viruses
Immunology
Enterovirus
Female
Rhinovirus
influenza
business
Zdroj: Influenza and Other Respiratory Viruses
ISSN: 1750-2659
1750-2640
Popis: Background Human rhinovirus/enterovirus (HRV/ENT) infections are commonly identified in children with acute respiratory infections (ARIs), but data on their clinical severity remain limited. Objectives We compared the clinical severity of HRV/ENT to respiratory syncytial virus (RSV), influenza A/B (FLU), and other common respiratory viruses in children. Patients/Methods Retrospective study of children with ARIs and confirmed single positive viral infections on mid-turbinate swabs by molecular assays. Outcome measures included hospital admission and, for inpatients, a composite endpoint consisting of intensive care admission, hospitalization >5 days, oxygen requirements or death. Results A total of 116 HRV/ENT, 102 RSV, 99 FLU, and 64 other common respiratory viruses were identified. Children with single HRV/ENT infections presented with significantly higher rates of underlying immunosuppressive conditions compared to those with RSV (37·9% versus 13·6%; P < 0·001), FLU (37·9% versus 22%; P = 0·018) or any other single viral infection (37·9% versus 22·5%; P = 0·024). In multivariable analysis adjusted for underlying conditions and age, children with HRV/ENT infections had increased odds of hospitalization compared to children with RSV infections (OR 2·6; 95% CI 1·4, 4·8; P < 0·003) or FLU infections (OR 3·0; 95% CI 1·6, 5·8
Databáze: OpenAIRE
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