Proton Beam Therapy in Combination with Intra-Arterial Infusion Chemotherapy for T4 Squamous Cell Carcinoma of the Maxillary Gingiva

Autor:	Ichiro Seto, Tatsuya Nakamura, Hitoshi Wada, Motohisa Suzuki, Kenji Mitsudo, Hisashi Yamaguchi, Hiromasa Endo, M. Murakami, Yusuke Azami, Kanako Takayama, Iwai Tohnai, Takashi Ono
Rok vydání:	2018
Předmět:	Cancer Research medicine.medical_specialty oral squamous cell carcinomas medicine.medical_treatment intra-arterial infusion chemotherapy Neutropenia lcsh:RC254-282 Article 030218 nuclear medicine & medical imaging chemoradiotherapy 03 medical and health sciences 0302 clinical medicine medicine Mucositis Lymph node Chemotherapy business.industry Therapeutic effect medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Primary tumor Radiation therapy proton beam therapy stomatognathic diseases medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Radiology business Chemoradiotherapy maxillary gingival cancer
Zdroj:	Cancers Cancers, Vol 10, Iss 9, p 333 (2018) Volume 10 Issue 9
ISSN:	2072-6694
Popis:	This study aimed to evaluate the therapeutic effect and toxicity of proton beam therapy in combination with intra-arterial infusion chemotherapy in patients with squamous cell carcinoma of the maxillary gingiva. Between December 2010 and March 2016, 30 patients with T4 squamous cell carcinoma of the maxillary gingiva were treated with radiotherapy and retrograde intra-arterial infusion chemotherapy using cisplatin (20&ndash 40 mg/m2, 4&ndash 6 times). Radiotherapy was basically administered using boost proton beam therapy for primary tumor and neck lymph node tumors, following 36&ndash 40 Gy photon radiation therapy delivered to the prophylactic area, to a total dose of 70.4&ndash 74.8 Gy. The median follow-up was 33 months. The 3-year local control and overall survival rates were 69% and 59%, respectively. Major grade 3 or higher acute toxicities included mucositis, neutropenia, and dermatitis in 12 (40%), 5 (17%), and 3 (10%) patients, respectively. No grade 3 or higher late toxicities were observed. These results suggested that proton beam therapy in combination with intra-arterial infusion chemotherapy was not inferior to other treatment protocols and should be considered as a safe and effective option in patients with T4 squamous cell carcinoma of the maxillary gingiva.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3cde78192d032bfe57853e09f25e97 https://pubmed.ncbi.nlm.nih.gov/30223580 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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