Percutaneous obliteration of the cystic duct with a holmium:yttrium-aluminum-garnet laser: results of in vitro and animal experiments
| Autor: | Yacov Domankevitz, Peter R. Mueller, Joseph T. Ferrucci, Sanjay Saini, M J Girard, Norman S. Nishioka, Thomas J. Flotte, M. Staritz |
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| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Percutaneous Time Factors Swine medicine.medical_treatment chemistry.chemical_element law.invention Cholangiography law Cholelithiasis Recurrence medicine Animals Radiology Nuclear Medicine and imaging Cholecystostomy Laser Coagulation medicine.diagnostic_test business.industry Gallbladder Cystic Duct General Medicine Laser Surgery medicine.anatomical_structure chemistry Cystic duct Feasibility Studies Female Holmium Nuclear medicine business Laser coagulation |
| Zdroj: | AJR. American journal of roentgenology. 159(5) |
| ISSN: | 0361-803X |
| Popis: | The purpose of this study was to investigate the feasibility of using a holmium:yttrium-aluminum-garnet laser to permanently occlude the cystic duct in order to isolate the gallbladder from the biliary-enteric circulation and prevent gallstone formation.To determine the optimal laser parameters (power and pulsing rate) for cystic duct thermocoagulation, 20 freshly excised porcine gallbladders with intact cystic ducts underwent low-energy (0.075-0.085 J/pulse) or high-energy (0.20-0.25 J/pulse) thermocoagulation. Histopathologic examination was done to determine the extent of cystic duct injury. After in vitro experiments, percutaneous transcholecystic laser thermocoagulation of the cystic duct was performed on 23 anesthetized domestic pigs (four controls). Cholangiograms immediately after laser thermocoagulation were obtained to assess cystic duct occlusion. Animals were sacrificed for histopathologic correlation immediately after laser thermocoagulation (n = 4), 72 hr later (n = 4), and 6 weeks later (n = 15).In the in vitro studies, all 10 cystic ducts in the high-energy group were occluded, while only four in the low-energy group were occluded. At histology, all cases in both groups showed circumferential injury to the cystic duct wall without injury to the cystic artery or vein. In the in vitro experiments, the cystic duct was successfully cannulated in 21 (91%) of 23 animals. Cholangiography after thermocoagulation showed occlusion of the cystic duct in 16 (84%) of 19 cases. Immediately after laser thermocoagulation, the cystic duct mucosa was circumferentially destroyed, whereas after 72 hr necrosis of the cystic duct wall and periductal tissues had occurred. By 6 weeks, all pigs had complete cystic duct fibrosis without injury to the common bile duct.Holmium:yttrium-aluminum-garnet laser thermocoagulation of the cystic duct can be performed easily, results in immediate cystic duct occlusion, and leads to permanent fibrous ductal obliteration by 6 weeks. |
| Databáze: | OpenAIRE |
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