An overview of the pathogenic mechanisms involved in severe cases of COVID-19 infection, and the proposal of salicyl-carnosine as a potential drug for its treatment
| Autor: | Rogneda B. Kazanskaya, Tatiana N. Fedorova, Anastasiya V Khutorova, A. V. Lopachev |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drug media_common.quotation_subject Pneumonia Viral Ischemia Carnosine Inflammation medicine.disease_cause Bioinformatics Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Animals Humans Pandemics media_common Pharmacology Aspirin business.industry COVID-19 Thrombosis Hypoxia (medical) medicine.disease Oxidative Stress 030104 developmental biology chemistry Salicyl-carnosine medicine.symptom business Coronavirus Infections 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | European Journal of Pharmacology |
| ISSN: | 1879-0712 |
| Popis: | Multiple organ failure in COVID-19 patients is a serious problem which can result in a fatal outcome. Damage to organs and tissues, including general lung dysfunction, develops as a consequence of ischemia, which, in turn, is caused by thrombosis in small blood vessels and hypoxia, leading to oxidative stress and inflammation. Currently, research is underway to screen existing drugs for antioxidant, antiplatelet and anti-inflammatory properties. Having studied the available publications concerning the mechanisms of damage to tissues and organs of patients with COVID-19, as well as the available treatment strategies, we propose to investigate salicyl-carnosine as a potential drug for treating COVID-19 patients. In a recent study, we described the drug's synthesis procedure, and showed that salicyl-carnosine possesses antioxidant, anti-inflammatory, and antiplatelet effects. Therefore, it can simultaneously act on the three pathogenetic factors involved in tissue and organ damage in COVID-19. Thus, we propose to consider salicyl-carnosine as a potential drug for the treatment of patients with severe cases of COVID-19 infection. |
| Databáze: | OpenAIRE |
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