Association of G1057D variant of insulin receptor substrate-2 with endometriosis
| Autor: | Lokman Ayaz, Filiz Çayan, Esen Akbay, Sevim Karakaş, Saffet Dilek, Özgür Çoban, Devrim Ertunc, Nurcan Aras-Ateş |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Genotype Population Endometriosis Severity of Illness Index Risk Factors Severity of illness medicine Humans Genetic Predisposition to Disease education Genotyping Gynecology Uterine Diseases education.field_of_study Polymorphism Genetic business.industry Case-control study Obstetrics and Gynecology Middle Aged medicine.disease IRS2 Reproductive Medicine Case-Control Studies Insulin Receptor Substrate Proteins Female Gene polymorphism business |
| Zdroj: | Fertility and sterility. 94(5) |
| ISSN: | 1556-5653 |
| Popis: | Objective To investigate whether the insulin receptor substrate (IRS)-2 G1057D polymorphism is associated with the risk of endometriosis, and to evaluate potential correlation of IRS2 gene polymorphism with the stages of endometriosis. Design Case-control study. Setting Gynecology clinics in university hospital. Patient(s) Women with (n = 135) or without (n = 135) endometriosis. Afterward, the women with endometriosis were divided into two groups according to the stage: group 1 included 63 women in stages I–II, and group 2 included 72 women in stages III–IV. Intervention(s) Genotyping by polymerase chain reaction–based restriction fragment-length polymorphism method. Main Outcome Measure(s) Genotype distribution of the G1057D polymorphism in the IRS2 gene. Result(s) The genotype distribution of the IRS2 G1057D polymorphism in the endometriosis group was significantly different from that of the control group (GG/GD/DD rates were 43.0%/39.3%/17.7% and 55.6%/36.3%/8.1% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis also revealed a positive association between the IRS2 DD genotype expression and stage III–IV endometriosis patients in the population studied. Conclusion(s) These results suggest that the IRS2 G1057D polymorphism may be associated with an increased risk for endometriosis. |
| Databáze: | OpenAIRE |
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