Progesterone anti-inflammatory properties in hereditary retinal degeneration

Autor: Teresa Olivar, Soledad Benlloch-Navarro, Laura Trachsel-Moncho, Inmaculada Almansa, José Miguel Soria, Ángel Fernández-Carbonell, María Miranda
Přispěvatelé: UCH. Departamento de Ciencias Biomédicas, Producción Científica UCH 2019
Rok vydání: 2019
Předmět:
0301 basic medicine
Retinal degeneration
Male
Conjunctiva - Diseases - Treatment
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Anti-Inflammatory Agents
Progesterona - Uso terapéutico
Biochemistry
Lipid peroxidation
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Cell Movement
Medicine
Progesterone
biology
Retinal Degeneration
Retinitis pigmentosa - Treatment
Eye - Diseases - Treatment
Nitric oxide synthase
medicine.anatomical_structure
Oftalmia - Tratamiento
030220 oncology & carcinogenesis
Ojos - Enfermedades - Tratamiento
Molecular Medicine
Female
Microglia
medicine.symptom
Retinitis Pigmentosa
medicine.medical_specialty
Inflammation
Progesterone - Therapeutic use
Retinitis pigmentaria - Tratamiento
03 medical and health sciences
Internal medicine
Retinitis pigmentosa
Animals
Molecular Biology
Retina
business.industry
Retinal
Cell Biology
medicine.disease
Mice
Inbred C57BL
Disease Models
Animal
030104 developmental biology
chemistry
biology.protein
Lipid Peroxidation
business
Hormone
Zdroj: CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
ISSN: 0960-0760
DOI: 10.1016/j.jsbmb.2019.01.007
Popis: Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.sciencedirect.com/science/article/abs/pii/S0960076018305077?via%3Dihub This is the pre-peer reviewed version of the following article: Benlloch-Navarro, S., Trachsel-Moncho, L., Fernández-Carbonell, Á., Olivar, T., Soria, J.M., Almansa, I. et al. (2019). Progesterone anti-inflammatory properties in hereditary retinal degeneration. Journal of Steroid Biochemistry and Molecular Biology, vol. 189 (may), pp. 291-301, which has been published in final form at https://doi.org/10.1016/j.jsbmb.2019.01.007. Este es el pre-print del siguiente artículo: Benlloch-Navarro, S., Trachsel-Moncho, L., Fernández-Carbonell, Á., Olivar, T., Soria, J.M., Almansa, I. et al. (2019). Progesterone anti-inflammatory properties in hereditary retinal degeneration. Journal of Steroid Biochemistry and Molecular Biology, vol. 189 (may), pp. 291-301, que se ha publicado de forma definitiva en https://doi.org/10.1016/j.jsbmb.2019.01.007. The interactions between steroid gonadal hormones and the retina (a part of the visual system and the central nervous system (CNS)) have received limited attention and beneficial effects of these hormones in retinal diseases is controversial. Retinitis pigmentosa (RP) is the most common cause of retinal hereditary blindness and to date no treatment is available. However, results regarding the effects of progesterone on the progression of RP are promising. With the idea of demonstrating if the progesterone retinal protection in RP is related to its possible anti-inflammatory properties, we have administered orally progesterone to rd10 mice, an animal model of RP. We observed that progesterone decreased photoreceptors cell death, reactive gliosis and the increase in microglial cells caused by RP. We also examined the expression of neuronal and inducible nitric oxide synthase (nNOS and iNOS), the enzyme responsible for NO production. The results demonstrated a decrease in nNOS expression only in control mice treated with progesterone. Inflammation has been related with an increase in lipid peroxidation. Noticeably progesterone administration was able to diminish retinal malondialdehyde (MDA, a lipid peroxidation product) concentrations in rd10 mice. Altogether, we can conclude that progesterone could be a good therapeutic option not only in RP but also for other retinal diseases that have been associated with inflammation and lipid peroxidation. Preprint
Databáze: OpenAIRE
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