Blood–Brain Barrier Breakdown and Edema Formation following Frontal Cortical Contusion: Does Hormonal Status Play a Role?
| Autor: | Robin L. Roof, Donald G. Stein, Stuart W. Hoffman, Revital Duvdevani, Zoltán Fülöp |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Pathology medicine.medical_specialty Time Factors Brain Edema Vascular permeability Blood–brain barrier Cerebral edema Capillary Permeability Rats Sprague-Dawley Central nervous system disease chemistry.chemical_compound medicine Animals Gonadal Steroid Hormones Brain Concussion Serum Albumin Evans Blue business.industry Anatomy medicine.disease Immunohistochemistry Pathophysiology Extravasation Frontal Lobe Rats medicine.anatomical_structure chemistry Blood-Brain Barrier Female Neurology (clinical) business Immunostaining |
| Zdroj: | Journal of Neurotrauma. 12:65-75 |
| ISSN: | 1557-9042 0897-7151 |
| Popis: | The present experiment was designed to evaluate and correlate the time course of blood–brain barrier (BBB) integrity and cerebral edema in adult male rats given medial frontal cortex contusions. The effect of sex hormones on BBB integrity in the same injury model was also examined, because previous work has shown that progesterone can reduce cerebral edema (Roof et al., 1993). BBB breakdown was assessed by Evans blue extravasation and albumin immunostaining while edema formation was measured by the wet weight dry weight technique. These processes were examined beginning 2 h and continuing up to 10 days after injury. Our findings show that medial frontal contusion in rats produces changes in cerebral water content and opening of the BBB that endures at least 7 days postinjury. Although pseudopregnancy has been shown to reduce cerebral edema at day 1 postinjury, we did not find any evidence that this hormonal state is associated with BBB repair. |
| Databáze: | OpenAIRE |
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