Clofarabine with topotecan, vinorelbine, and thiotepa reinduction regimen for children and young adults with relapsed AML
| Autor: | Kavitha Ramaswamy, Peter G. Steinherz, Anurag K. Agrawal, Christopher J. Forlenza, Audrey Mauguen, Mikhail Roshal, Tanya Trippett, Nancy A. Kernan, Maria Luisa Sulis, Neerav Shukla |
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| Rok vydání: | 2022 |
| Předmět: |
Myeloid
Pediatric Leukemia Pediatric Cancer Childhood Leukemia Clinical Trials and Supportive Activities Vinorelbine Hematology Acute Leukemia Myeloid Acute Young Adult Rare Diseases Clinical Research Recurrence Antineoplastic Combined Chemotherapy Protocols Humans Anthracyclines Child Topotecan Thiotepa Cancer Clofarabine |
| Zdroj: | Blood advances, vol 6, iss 8 |
| ISSN: | 2473-9537 2473-9529 |
| DOI: | 10.1182/bloodadvances.2021005753 |
| Popis: | Effective reinduction regimens are needed for children with relapsed and refractory acute myeloid leukemia (AML), as outcomes remain poor. Therapeutic options are limited in this heavily pretreated patient population, many of whom have reached lifetime recommended doses of anthracycline chemotherapy. The development of effective non-anthracycline–based salvage regimens is crucial to these patients who are at significant risk of life-threatening cardiotoxicity. We previously reported results of a phase 2 trial of a clofarabine-based regimen with topotecan, vinorelbine, and thiotepa (TVTC) in patients with relapsed acute leukemias. Here we report on an expanded bicenter cohort of 33 patients |
| Databáze: | OpenAIRE |
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