Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson’s disease
| Autor: | Stanislav Dusko Ehrlich, Gordon Proctor, Mathias Uhlén, Saeed Shoaie, Falk Hildebrand, Sunjae Lee, Janis R. Bedarf, Dorines Rosario, Gholamreza Bidkhori, Adil Mardinoglu, Ullrich Wüllner |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Parkinson's disease Disease Gut flora Bioinformatics metabolism [Polysaccharides] Severity of Illness Index 0302 clinical medicine metabolic modeling blood [Parkinson Disease] Databases Genetic Medicine Homocysteine blood [Folic Acid Deficiency] biology gut-brain axis Parkinson Disease Middle Aged microbiology [Parkinson Disease] Intestines Metabolome Hyperhomocysteinemia blood [Homocysteine] Gut–brain axis microbiology [Intestines] Folic Acid Deficiency metabolism [Bacteria] blood [Hyperhomocysteinemia] General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Folic Acid Metabolomics Polysaccharides genetics [Gastrointestinal Microbiome] metabolism [Mucins] Humans ddc:610 Aged metagenomics Bacteria genetics [Bacteria] gut microbiota business.industry Mucins microbiology [Hyperhomocysteinemia] biology.organism_classification medicine.disease Gastrointestinal Microbiome 030104 developmental biology Metagenomics Case-Control Studies microbiology [Folic Acid Deficiency] Parkinson’s disease Dysbiosis Metagenome Enteric nervous system blood [Folic Acid] business 030217 neurology & neurosurgery |
| Zdroj: | Cell reports 34(9), 108807 (2021). doi:10.1016/j.celrep.2021.108807 |
| ISSN: | 2211-1247 |
| Popis: | Parkinson's disease (PD) is the most common progressive neurological disorder compromising motor functions. However, nonmotor symptoms, such as gastrointestinal (GI) dysfunction, precede those affecting movement. Evidence of an early involvement of the GI tract and enteric nervous system highlights the need for better understanding of the role of gut microbiota in GI complications in PD. Here, we investigate the gut microbiome of patients with PD using metagenomics and serum metabolomics. We integrate these data using metabolic modeling and construct an integrative correlation network giving insight into key microbial species linked with disease severity, GI dysfunction, and age of patients with PD. Functional analysis reveals an increased microbial capability to degrade mucin and host glycans in PD. Personalized community-level metabolic modeling reveals the microbial contribution to folate deficiency and hyperhomocysteinemia observed in patients with PD. The metabolic modeling approach could be applied to uncover gut microbial metabolic contributions to PD pathophysiology. |
| Databáze: | OpenAIRE |
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