Effect of sılymarın on oxıdatıve stress and lıver hıstopathology ın experımental obstructıve jaundıce model
| Autor: | Salih Tuncal, Erdinç Devrim, Kemal Kismet, Esra Durak, Bulent Kilicoglu, Salih Celepli, Aziz Mutlu Barlas, Ali Kemal Onalan, Sibel Serin Kilicoglu |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty RD1-811 medicine.medical_treatment Jaundice medicine.disease_cause Protective Agents Gastroenterology Antioxidants 03 medical and health sciences chemistry.chemical_compound Random Allocation 0302 clinical medicine Edema Internal medicine Laparotomy Malondialdehyde Medicine Animals Rats Wistar Ligation business.industry Bile duct Obstructive Glutathione Rats Jaundice Obstructive Oxidative Stress medicine.anatomical_structure chemistry Liver 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Surgery Female Bile Ducts medicine.symptom business Oxidative stress Silymarin |
| Zdroj: | Acta Cirúrgica Brasileira v.31 n.12 2016 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Volume: 31, Issue: 12, Pages: 801-806, Published: DEC 2016 Acta Cirurgica Brasileira, Vol 31, Iss 12, Pp 801-806 (2016) |
| ISSN: | 1678-2674 |
| Popis: | PURPOSE: To investigate the effect of silymarin on oxidative stress and hepatic injury induced by obstructive jaundice in an experimental model. METHODS: Thirty Wistar-Albino type female rats were divided into 3 groups each including 10 rats. Only laparotomy was performed in group 1. Bile duct ligation was performed in group 2. In group 3, bile duct ligation was performed and orogastic silymarin 300 mg/kg/day dose was given for seven days. At the end of seven days, rats were sacrificed. The blood and liver tissue samples were taken to be examined biochemically and histopathologically. RESULTS: The plasma and liver levels of malondialdehyde were significantly lower in silymarin group than in the bile duct ligated group. Although liver levels of GSH were significantly higher in silymarin group than in the bile duct ligated group, there was no significant difference between the plasma GSH levels of these groups. In silymarin group; the enlargement of hepatocytes, dilatation of canaliculi and the edema were regressed. CONCLUSION: Silymarin diminished the harmful effects of obstructive jaundice on liver. |
| Databáze: | OpenAIRE |
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