Whole Body Low Dose Computed Tomography (WBLDCT) Can Be Comparable to Whole-Body Magnetic Resonance Imaging (WBMRI) in the Assessment of Multiple Myeloma
| Autor: | Davide Gandola, Cesare Maino, Pietro Andrea Bonaffini, Maria Ragusi, Teresa Giandola, Sandro Sironi, Davide Ippolito |
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| Přispěvatelé: | Ippolito, D, Giandola, T, Maino, C, Gandola, D, Ragusi, M, Bonaffini, P, Sironi, S |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
Clinical Biochemistry multidetector computed tomography Lesion Number Focal Pattern Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Cohen's kappa R5-920 Hematologic neoplasm medicine magnetic resonance imaging hematologic neoplasms Pelvis Osteolysi Rib cage medicine.diagnostic_test business.industry Magnetic resonance imaging multiple myeloma Skull medicine.anatomical_structure 030220 oncology & carcinogenesis radiation dosage osteolysis diffusion-weighted imaging Diffusion-weighted imaging Nuclear medicine business Diffusion MRI |
| Zdroj: | Diagnostics, Vol 11, Iss 857, p 857 (2021) Diagnostics; Volume 11; Issue 5; Pages: 857 Diagnostics |
| ISSN: | 2075-4418 |
| Popis: | Aim of the study is to compare the agreement between whole-body low-dose computed tomography (WBLDCT) and magnetic resonance imaging (WBMRI) in the evaluation of bone marrow involvement in patients with multiple myeloma (MM). Patients with biopsy-proven MM, who underwent both WBLDCT and WBMRI were retrospectively enrolled. After identifying the presence of focal bone involvement (focal infiltration pattern), the whole skeleton was divided into five anatomic districts (skull, spine, sternum and ribs, pelvis, and limbs). Patients were grouped according to the number and location of the lytic lesions (20) and Durie and Salmon staging system. The agreement between CT and MRI regarding focal pattern, staging, lesion number, and distribution was assessed using the Cohen Kappa statistics. The majority of patients showed focal involvement. According to the distribution of the focal lesions and Durie Salmon staging, the agreement between CT and MRI was substantial or almost perfect (all κ > 0.60). The agreement increased proportionally with the number of lesions in the pelvis and spine (κ = 0.373 to κ = 0.564, and κ = 0.469–0.624), while for the skull the agreement proportionally decreased without reaching a statistically significant difference (p > 0.05). In conclusion, WBLDCT showed an almost perfect agreement in the evaluation of focal involvement, staging, lesion number, and distribution of bone involvement in comparison with WBMRI. |
| Databáze: | OpenAIRE |
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