CD27 is required for protective lytic EBV antigen–specific CD8+ T-cell expansion
| Autor: | Patrick Schuhmachers, Antonino Bongiovanni, Hans J. Stauss, Kyra D. Zens, Angelika Holler, Yun Deng, Hana Zdimerova, Riccarda Capaul, Andrea Zbinden, Laure-Anne Ligeon, Wolfgang Hammerschmidt, Christian Münz, Anne Müller, Bithi Chatterjee |
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| Rok vydání: | 2021 |
| Předmět: |
Epstein-Barr Virus Infections
Herpesvirus 4 Human Immunobiology and Immunotherapy Immunology Mice Transgenic chemical and pharmacologic phenomena CD8-Positive T-Lymphocytes medicine.disease_cause Biochemistry Mice Immune system Antigen Mice Inbred NOD hemic and lymphatic diseases medicine Animals Humans Cytotoxic T cell CD70 B-Lymphocytes Immunity Cellular biology Chemistry Cell Biology Hematology Cell Transformation Viral Phosphoproteins Epstein–Barr virus Tumor Necrosis Factor Receptor Superfamily Member 7 Lytic cycle Trans-Activators biology.protein Cancer research Antibody CD8 |
| Zdroj: | Blood Blood 137, 3225-3236 (2021) |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27+ cells and antibody blocking of CD27 interaction with CD70 cause uncontrolled EBV infection in mice with reconstituted human immune system components. While overall CD8+ T-cell expansion and composition are unaltered after antibody blocking of CD27, only some EBV-specific CD8+ T-cell responses, exemplified by early lytic EBV antigen BMLF1-specific CD8+ T cells, are inhibited in their proliferation and killing of EBV-transformed B cells. This suggests that CD27 is not required for all CD8+ T-cell expansions and cytotoxicity but is required for a subset of CD8+ T-cell responses that protect us from EBV pathology. |
| Databáze: | OpenAIRE |
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