A High Carbohydrate Diet Induces Insulin Resistance Through Decreased Glucose Utilization in Ovariectomized Rats
| Autor: | Chun Hee Park, Jun Dong Wha, Sun Min Park, Soo Bong Choi |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Blood Glucose
Leptin Sucrose medicine.medical_specialty Time Factors Ovariectomy medicine.medical_treatment Rats Sprague-Dawley chemistry.chemical_compound Insulin resistance Glucose transporter 4 Internal medicine Dietary Carbohydrates medicine Animals Insulin Euglycemic hyperinsulinemic clamp Glycogen synthase activity Muscle Skeletal Glycogen synthase Triglycerides Glucose Transporter Type 4 Estradiol Glycogen biology business.industry Body Weight Glucose transporter Carbohydrate Glucose clamp technique medicine.disease Rats Glycogen Synthase Endocrinology chemistry Models Animal Glucose Clamp Technique Ovariectomized rat biology.protein Original Article Female Insulin Resistance Energy Intake business hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Korean Journal of Internal Medicine |
| ISSN: | 2005-6648 1226-3303 |
| DOI: | 10.3904/kjim.2004.19.2.87 |
| Popis: | BACKGROUND: Recent research has reported that high sugar diets increase insulin resistance, without abdominal obesity, in male, but not female Wistar rats. Whether a high sucrose (SU) diet increased insulin resistance in ovariectomized (OVX) rats was determined. METHODS: Female Sprague Dawley rats, weighing 273 +/- 20 g, had either an ovariectomy or a sham operation (sham). OVX and sham rats were divided into two groups: one group had a 68 En% SU diet and the other a 68 En% starch (ST) diet for 8 weeks. RESULTS: The body weight was higher in the OVX than the sham rats, regardless of dietary carbohydrate subtype. The fasting serum glucose levels did not differ according to diet and ovariectomy. However, the fasting serum insulin levels were higher in the OVX than the sham rats, and in the OVX rats, a high SU diet increased the serum insulin levels more than a high ST diet. The whole body glucose disposal rates, which referred to the state of insulin sensitivity, were lower in the OVX rats fed both the high SU and ST diets, compared to sham rats. Glycogen deposits in the soleus and quadriceps muscles were lower in the OVX rats fed high SU and ST diets than in sham rats. The glucose transporter 4 content and fraction velocity of glycogen synthase in muscles showed similar glucose disposal rates. However, the triacylglycerol content in the muscles were higher in the OVX rats with a high SU diet than those with a high ST diet. CONCLUSION: These results suggested that an OVX increased the weight gain due to higher food intakes, regardless of dietary carbohydrate subtypes. OVX-induced obesity may be involved in the induction of insulin resistance from an increased triacylglycerol content, decreased glucose uptake and glycogen synthesis in skeletal muscles, regardless of dietary carbohydrate subtypes. |
| Databáze: | OpenAIRE |
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