Antidiabetic and Antilipidemic Activity of Root Extracts of Salacia oblonga against Streptozotocin-Induced Diabetes in Wistar Rats
| Autor: | Ganta Suhasin, Hosam O. Elansary, Neelapu Nagesewara Rao Reddy, Surekha Challa, Diaa O. El-Ansary, Kakara Gift Kumar Deepak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Bilirubin
medicine.medical_treatment Intraperitoneal injection Bioengineering lcsh:Chemical technology 01 natural sciences α-glucosidase inhibitors lcsh:Chemistry chemistry.chemical_compound Diabetes mellitus medicine Chemical Engineering (miscellaneous) lcsh:TP1-1185 Acarbose Traditional medicine biology 010405 organic chemistry Salacia oblonga business.industry antidiabetic Process Chemistry and Technology medicine.disease biology.organism_classification Streptozotocin Acute toxicity antilipidemic 0104 chemical sciences 010404 medicinal & biomolecular chemistry n/a chemistry lcsh:QD1-999 Toxicity diabetes mellitus salacia oblonga business acarbose medicine.drug |
| Zdroj: | Processes, Vol 8, Iss 3, p 301 (2020) Processes Volume 8 Issue 3 |
| ISSN: | 2227-9717 |
| Popis: | Salacia oblonga is used to treat diabetes, hypocholesteremia, gonorrhea, rheumatism, asthma, inflammation, oxidative stress, etc. In the present study, the antidiabetic activity of S. oblonga methanolic root extracts collected from three geographical locations, viz., Eleshwaram (Andhra Pradesh), Thoothukudi (Tamil Nadu), and Karwar (Karnataka), was studied in vitro. Among the three extracts, S. oblonga root extracts from Eleshwaram showed maximum α-glucosidase and α-amylase inhibitory activities, indicating better antidiabetic activity. Acute toxicity studies of S. oblonga carried out in Albino Wistar rats showed no toxicity. Further, in vivo studies showed antidiabetic and antilipidemic activities in Albino Wistar rats with induced type II diabetes mellitus. Type II diabetes mellitus was induced in the experimental rats by intraperitoneal injection of nicotinamide and streptozotocin. The rats were orally fed different doses (ranging from 0 to 400 mg/kg body weight) of S. oblonga root extracts from Eleshwaram for 14 days. Blood glucose, lipid, bilirubin, and creatinine levels were analyzed on day 0, 7, and 14. The S. oblonga root extract from Eleshwaram decreased the glucose levels in a dose-dependent manner as well as the lipid, creatinine, and bilirubin levels in diabetic rats. Thus, the present study demonstrates antidiabetic and antilipidemic properties of S. oblonga root extracts. |
| Databáze: | OpenAIRE |
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