Synthesis of F-18 labeled resazurin by direct electrophilic fluorination
| Autor: | Sarah J. Saylor, E. James Delikatny, Alejandro D. Arroyo, Alexander V. Kachur, Anatoliy V. Popov |
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| Rok vydání: | 2015 |
| Předmět: |
Organic Chemistry
Electrophilic fluorination chemistry.chemical_element Resazurin Photochemistry Biochemistry Article Inorganic Chemistry chemistry.chemical_compound Optical imaging chemistry Bathochromic shift Fluorine Environmental Chemistry Organic chemistry Viability assay Physical and Theoretical Chemistry Absorption (chemistry) Luminescence |
| Zdroj: | Journal of fluorine chemistry. 178 |
| ISSN: | 0022-1139 |
| Popis: | We present the synthesis and characterization of F18-labeled fluorinated derivatives of resazurin, a probe for cell viability. The compounds were prepared by direct fluorination of resazurin with diluted [F18]-F2 gas under acidic conditions. The fluorination occurs into the ortho-positions to the hydroxyl group producing various mono-, di-, and trifluorinated derivatives. The properties of the fluorinated resazurins are similar to the parent compound with the addition of fluorine leading to decreased pKa values and a bathochromic shift of the absorption maxima. The fluorinated resazurin derivatives can be used as probes for observation of cell viability in various cells, tissues and organs using a combination of positron emission tomography and direct optical imaging of Cerenkov luminescence. |
| Databáze: | OpenAIRE |
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