Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age-related macular degeneration before, during, and after treatment with ranibizumab

Autor: Alexandre Antonio Marques Rosa, Edmundo Frota de Almeida Sobrinho, Givago da Silva Souza, Luiz Carlos L. Silveira, Luciana Negrão Frota de Almeida, Bruno Gomes, Izabela Almeida
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
Time Factors
optical coherence
genetic structures
Anticorpos monoclonais humanizado/uso terapêutico
Visual Acuity
Angiogenesis Inhibitors
Injeções intravítreas
chemistry.chemical_compound
Macular Degeneration
lcsh:Ophthalmology
Edema
Medicine
Tomography
Intravitreal injections
medicine.diagnostic_test
General Medicine
medicine.anatomical_structure
Treatment Outcome
Tomografia de coerência óptica
Intravitreal Injections
Female
Macular degeneration/drug therapy
medicine.symptom
Tomography
Optical Coherence
medicine.drug
medicine.medical_specialty
Degeneração macular/quimioterapia
Antibodies
Monoclonal
Humanized
Retina
Antibodies
Optical coherence tomography
Ophthalmology
Ranibizumab
Electroretinography
Humans
Aged
Analysis of Variance
business.industry
Reproducibility of Results
Retinal
Macular degeneration
medicine.disease
monoclonal
humanized/therapeutic use
eye diseases
Eletrorretinografia
Surgery
chemistry
lcsh:RE1-994
Multifocal electroretinography
sense organs
business
Zdroj: Arquivos Brasileiros de Oftalmologia v.78 n.2 2015
Arquivos brasileiros de oftalmologia
Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
Arquivos Brasileiros de Oftalmologia, Vol 78, Iss 2, Pp 105-109 (2015)
Arquivos Brasileiros de Oftalmologia, Volume: 78, Issue: 2, Pages: 105-109, Published: APR 2015
Popis: Purpose: To evaluate retinal morphology and function of patients with advanced neovascular age-related macular degeneration (AMD) before, during, and after treatment with ranibizumab. Methods: Twenty-one eyes diagnosed with advanced AMD were studied with optical coherence tomography (OCT) and multifocal electroretinography (mfERG). Three intravitreal injections of ranibizumab were administered at 1-month intervals. Evaluations were performed before the first injection (D0) and at 30 (D30), 60 (D60), and 90 days (D90) after the first injection and compared to an age-matched control group (n=21 eyes). Results: The thickness of macular retinal layers increased before treatment due to the presence of intraretinal fluid. A thick retinal pigment epithelium-choriocapillaris complex (RPE-CC) suggested the presence of choroidal neovascular membrane. Intraretinal edema decreased after treatment (P
Databáze: OpenAIRE
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