Reaction of arene oxides with nucleosides
| Autor: | H. Friesel, E. Hecker |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Cancer Research
Alkylation Chemical Phenomena Guanosine 9 10-Dimethyl-1 2-benzanthracene In Vitro Techniques Phenanthrenes medicine.disease_cause Medicinal chemistry Inosine Chemistry Hydrolysis chemistry.chemical_compound Oncology chemistry Biochemistry Yield (chemistry) Benz(a)Anthracenes medicine Sodium carbonate Ultraviolet medicine.drug |
| Zdroj: | Cancer Letters. 3:169-175 |
| ISSN: | 0304-3835 |
| Popis: | Summary Inosine was reacted with phenanthrene-9,10-oxide and 7,12-dimethylbenz(a)anthracene-5,6-oxide (DMBA-5,6-oxide) to yield the corresponding N -1-alkylinosines. They were shown to undergo hydrolysis to 5-amino-4-imidazole- N -alkylcarboxamide ribosides when heated in the presence of sodium carbonate. Guanosine was reacted with DMBA-5,6-oxide to yield a mixture of N -7-alkylguanines along with a smaller amount of an orcine positive product exhibiting an ultraviolet spectrum resembling that of DMBA-5,6-dihydrodiol. |
| Databáze: | OpenAIRE |
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