The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease
| Autor: | Johan Auwerx, Virginija Jovaisaite, Laurent Mouchiroud |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Aging
Protein Folding Physiology Context (language use) Aquatic Science Mitochondrion Biology Endoplasmic Reticulum Cellular Stress 03 medical and health sciences 0302 clinical medicine Stress Physiological Mitochondrial unfolded protein response Chaperones Animals Heat shock Caenorhabditis elegans Molecular Biology Heat-Shock Proteins Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences Endoplasmic reticulum Signaling Mitochondria Cell biology Proteostasis Insect Science Unfolded Protein Response Unfolded protein response Animal Science and Zoology Signal transduction Heat-Shock Response 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Journal of Experimental Biology |
| ISSN: | 1477-9145 0022-0949 |
| DOI: | 10.1242/jeb.090738 |
| Popis: | The ability to respond to various intracellular and/or extracellular stresses allows the organism to adapt to changing environmental conditions and drives evolution. It is now well accepted that a progressive decline of the efficiency of stress response pathways occurs with aging. In this context, a correct proteostasis is essential for the functionality of the cell, and its dysfunction has been associated with protein aggregation and age-related degenerative diseases. Complex response mechanisms have evolved to deal with unfolded protein stress in different subcellular compartments and their moderate activation translates into positive effects on health. In this review, we focus on the mitochondrial unfolded protein response (UPRmt), a response to proteotoxic stress specifically in mitochondria, an organelle with a wide array of fundamental functions, most notably the harvesting of energy from food and the control of cell death. We compare UPRmt with the extensively characterized cytosolic heat shock response (HSR) and the unfolded protein response in endoplasmic reticulum (UPRER), and discuss the current knowledge about UPRmt signaling pathways as well as their potential involvement in physiology. |
| Databáze: | OpenAIRE |
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