Prospective association of physical activity and inflammatory biomarkers in older adults from the PREDIMED-Plus study with overweight or obesity and metabolic syndrome
Autor: | Josep Vidal, Helmut Schröder, F. Aros, Dolores Corella, Pilar Buil-Cosiales, Olga Castañer, Gabriela Cárdenas Fuentes, Montserrat Fitó, Lluis Serra-Majem, Julia Wärnberg, Josep A. Tur, Ramon Estruch, Xavier Pintó, Isaac Subirana, Clotilde Vázquez, Jordi Salas-Salvadó, Mònica Bulló, Dora Romaguera, J. Alfredo Martínez |
---|---|
Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Health Knowledge Attitudes Practice medicine.medical_specialty Time Factors 030209 endocrinology & metabolism Overweight Diet Mediterranean Critical Care and Intensive Care Medicine Risk Assessment law.invention 03 medical and health sciences 0302 clinical medicine Patient Education as Topic Randomized controlled trial Risk Factors law Internal medicine Humans Medicine Obesity Prospective Studies Interleukin 6 Prospective cohort study Exercise Aged Metabolic Syndrome 030109 nutrition & dietetics Nutrition and Dietetics biology business.industry Age Factors Middle Aged medicine.disease 3. Good health Clinical trial Treatment Outcome Spain biology.protein Cytokines Female Interleukin 18 Diet Healthy Inflammation Mediators Metabolic syndrome medicine.symptom business Biomarkers |
Zdroj: | Clinical Nutrition. 39:3092-3098 |
ISSN: | 0261-5614 |
Popis: | Summary Background There is limited prospective evidence on the association between physical activity (PA) and inflammation in older adults. Our aim was to assess the associations between changes in PA and changes in the inflammatory profile in older individuals who are overweight or obese. Methods This prospective study included 489 men and women, aged 55–75 years, from the PREDIMED-Plus trial. Levels of interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 18 (IL-18), monocyte chemo-attractant protein-1 (MCP-1), C-peptide, high-sensitivity C-reactive protein (hs-CRP), leptin, and regulated on activation, normal T-cell expressed and secreted chemokine (RANTES) were obtained from fasting blood samples and a composite inflammatory score based on these biomarkers was calculated. Physical activity was measured by a validated questionnaire. All measures were taken at baseline and one-year follow-up. Results Multiple linear regression models showed an association between an increase in total PA and a decrease in the inflammatory score (p = 0.012), which was particularly driven by a decrease in C-peptide (p = 0.037). Similarly, the inflammatory score decreased with increasing moderate PA (p = 0.001), and moderate-to-vigorous PA (p = 0.006). Conclusions Increases in total PA, moderate and moderate-to-vigorous PA were associated with a decrease in the inflammatory profile of obese or overweight older individuals. This finding is relevant for PA recommendations and public health strategies. Clinical trial registry Clinical trial identifier: International Standard Randomized Controlled Trial 89898870. |
Databáze: | OpenAIRE |
Externí odkaz: |