Prospective association of physical activity and inflammatory biomarkers in older adults from the PREDIMED-Plus study with overweight or obesity and metabolic syndrome

Autor: Josep Vidal, Helmut Schröder, F. Aros, Dolores Corella, Pilar Buil-Cosiales, Olga Castañer, Gabriela Cárdenas Fuentes, Montserrat Fitó, Lluis Serra-Majem, Julia Wärnberg, Josep A. Tur, Ramon Estruch, Xavier Pintó, Isaac Subirana, Clotilde Vázquez, Jordi Salas-Salvadó, Mònica Bulló, Dora Romaguera, J. Alfredo Martínez
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Health Knowledge
Attitudes
Practice
medicine.medical_specialty
Time Factors
030209 endocrinology & metabolism
Overweight
Diet
Mediterranean
Critical Care and Intensive Care Medicine
Risk Assessment
law.invention
03 medical and health sciences
0302 clinical medicine
Patient Education as Topic
Randomized controlled trial
Risk Factors
law
Internal medicine
Humans
Medicine
Obesity
Prospective Studies
Interleukin 6
Prospective cohort study
Exercise
Aged
Metabolic Syndrome
030109 nutrition & dietetics
Nutrition and Dietetics
biology
business.industry
Age Factors
Middle Aged
medicine.disease
3. Good health
Clinical trial
Treatment Outcome
Spain
biology.protein
Cytokines
Female
Interleukin 18
Diet
Healthy
Inflammation Mediators
Metabolic syndrome
medicine.symptom
business
Biomarkers
Zdroj: Clinical Nutrition. 39:3092-3098
ISSN: 0261-5614
Popis: Summary Background There is limited prospective evidence on the association between physical activity (PA) and inflammation in older adults. Our aim was to assess the associations between changes in PA and changes in the inflammatory profile in older individuals who are overweight or obese. Methods This prospective study included 489 men and women, aged 55–75 years, from the PREDIMED-Plus trial. Levels of interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 18 (IL-18), monocyte chemo-attractant protein-1 (MCP-1), C-peptide, high-sensitivity C-reactive protein (hs-CRP), leptin, and regulated on activation, normal T-cell expressed and secreted chemokine (RANTES) were obtained from fasting blood samples and a composite inflammatory score based on these biomarkers was calculated. Physical activity was measured by a validated questionnaire. All measures were taken at baseline and one-year follow-up. Results Multiple linear regression models showed an association between an increase in total PA and a decrease in the inflammatory score (p = 0.012), which was particularly driven by a decrease in C-peptide (p = 0.037). Similarly, the inflammatory score decreased with increasing moderate PA (p = 0.001), and moderate-to-vigorous PA (p = 0.006). Conclusions Increases in total PA, moderate and moderate-to-vigorous PA were associated with a decrease in the inflammatory profile of obese or overweight older individuals. This finding is relevant for PA recommendations and public health strategies. Clinical trial registry Clinical trial identifier: International Standard Randomized Controlled Trial 89898870.
Databáze: OpenAIRE
Externí odkaz: