Renin-angiotensin system gene polymorphisms and premature coronary heart disease

Autor: F. Sirri Cam, Afig Berdeli, Ertugrul Ercan, Istemihan Tengiz, Mustafa Akin, Abdi Sagcan, Cevad Sekuri, Erhan Eser
Přispěvatelé: Ege Üniversitesi
Rok vydání: 2005
Předmět:
Adult
Male
Medicine (General)
medicine.medical_specialty
Time Factors
Genotype
Turkey
Angiotensinogen
Coronary Disease
Peptidyl-Dipeptidase A
030204 cardiovascular system & hematology
Polymerase Chain Reaction
Receptor
Angiotensin
Type 1

03 medical and health sciences
R5-920
0302 clinical medicine
Endocrinology
Gene Frequency
Polymorphism (computer science)
Internal medicine
Odds Ratio
Internal Medicine
Humans
Medicine
Genetic Predisposition to Disease
030212 general & internal medicine
Allele frequency
Cardiovascular risk factors
Polymorphism
Genetic

Angiotensin II receptor type 1
business.industry
ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS
Gene polymorphism
Case-control study
Middle Aged
Angiotensin II
ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS
ComputingMethodologies_PATTERNRECOGNITION
Premature coronary heart disease
Case-Control Studies
Female
InformationSystems_MISCELLANEOUS
Renin-angiotensin system
Restriction fragment length polymorphism
business
Polymorphism
Restriction Fragment Length
Zdroj: Journal of the Renin-Angiotensin-Aldosterone System, Vol 6 (2005)
ISSN: 1752-8976
1470-3203
DOI: 10.3317/jraas.2005.005
Popis: PubMed ID: 16088850
Introduction: Experimental and clinical studies demonstrated that the renin-angiotensin system (RAS) affects the pathogenesis of atherosclerosis and prognosis of coronary heart disease (CHD). The aim of this study was to investigate the genotype distribution and the allele frequencies of three RAS genes polymorphisms and their effects on premature CHD in a Turkish population. Materials and methods: One-hundred and fifteen Turkish patients with premature CHD and 128 controls were included into the study. Angiotensin-converting enzyme (ACE), angiotensin II type 1 (AT1) receptor and angiotensinogen (AGT) gene polymorphisms were analysed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results: The patients group showed an increased frequency of the ACE D allele compared with controls (65% vs. 35%, p-0.0001). There was a significant association between the DD genotype and premature CHD (ACE DD vs. ID and II; odds ratio [OR]=2.82 [CI 95% 1.33-2.91, P=0.002]). Also, we observed increased premature CHD risk associated with higher frequencies of the AGT MM genotype in patients when compared with controls (AGT MM vs. TT and MT, OR=1.92 [CI 95% 1.11-3-33, p=0.018]). We found a significant association between AT1-receptor AA genotype and decreased risk of premature CHD (AT1R AA vs. AC and CC, OR=0.57[CI 95% 0.34-0.95, p=0.03]). Conclusions: We demonstrated that increased premature CHD risk is associated with higher frequencies of the ACE DD and AGT MM genotypes. These findings indicate a synergistic contribution of ACE DD and AGT MM polymorphisms to the development of premature CHD. Also, our results suggest that family history, smoking, diabetes, hypertension, obesity and ACE DD genotype were independent risk factors for premature CHD.
Databáze: OpenAIRE