Renin-angiotensin system gene polymorphisms and premature coronary heart disease
Autor: | F. Sirri Cam, Afig Berdeli, Ertugrul Ercan, Istemihan Tengiz, Mustafa Akin, Abdi Sagcan, Cevad Sekuri, Erhan Eser |
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Přispěvatelé: | Ege Üniversitesi |
Rok vydání: | 2005 |
Předmět: |
Adult
Male Medicine (General) medicine.medical_specialty Time Factors Genotype Turkey Angiotensinogen Coronary Disease Peptidyl-Dipeptidase A 030204 cardiovascular system & hematology Polymerase Chain Reaction Receptor Angiotensin Type 1 03 medical and health sciences R5-920 0302 clinical medicine Endocrinology Gene Frequency Polymorphism (computer science) Internal medicine Odds Ratio Internal Medicine Humans Medicine Genetic Predisposition to Disease 030212 general & internal medicine Allele frequency Cardiovascular risk factors Polymorphism Genetic Angiotensin II receptor type 1 business.industry ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS Gene polymorphism Case-control study Middle Aged Angiotensin II ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ComputingMethodologies_PATTERNRECOGNITION Premature coronary heart disease Case-Control Studies Female InformationSystems_MISCELLANEOUS Renin-angiotensin system Restriction fragment length polymorphism business Polymorphism Restriction Fragment Length |
Zdroj: | Journal of the Renin-Angiotensin-Aldosterone System, Vol 6 (2005) |
ISSN: | 1752-8976 1470-3203 |
DOI: | 10.3317/jraas.2005.005 |
Popis: | PubMed ID: 16088850 Introduction: Experimental and clinical studies demonstrated that the renin-angiotensin system (RAS) affects the pathogenesis of atherosclerosis and prognosis of coronary heart disease (CHD). The aim of this study was to investigate the genotype distribution and the allele frequencies of three RAS genes polymorphisms and their effects on premature CHD in a Turkish population. Materials and methods: One-hundred and fifteen Turkish patients with premature CHD and 128 controls were included into the study. Angiotensin-converting enzyme (ACE), angiotensin II type 1 (AT1) receptor and angiotensinogen (AGT) gene polymorphisms were analysed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results: The patients group showed an increased frequency of the ACE D allele compared with controls (65% vs. 35%, p-0.0001). There was a significant association between the DD genotype and premature CHD (ACE DD vs. ID and II; odds ratio [OR]=2.82 [CI 95% 1.33-2.91, P=0.002]). Also, we observed increased premature CHD risk associated with higher frequencies of the AGT MM genotype in patients when compared with controls (AGT MM vs. TT and MT, OR=1.92 [CI 95% 1.11-3-33, p=0.018]). We found a significant association between AT1-receptor AA genotype and decreased risk of premature CHD (AT1R AA vs. AC and CC, OR=0.57[CI 95% 0.34-0.95, p=0.03]). Conclusions: We demonstrated that increased premature CHD risk is associated with higher frequencies of the ACE DD and AGT MM genotypes. These findings indicate a synergistic contribution of ACE DD and AGT MM polymorphisms to the development of premature CHD. Also, our results suggest that family history, smoking, diabetes, hypertension, obesity and ACE DD genotype were independent risk factors for premature CHD. |
Databáze: | OpenAIRE |
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