4D perfusion CT of prostate cancer for image-guided radiotherapy planning: A proof of concept study
| Autor: | Georg Schatzl, Paul Apfaltrer, Harald Herrmann, Alexander K. Brendel, Helmut Ringl, Peter R. Mazal, Thomas H. Helbich, Stephan H. Polanec, Christian Schestak, Dietmar Georg, Pascal A. T. Baltzer, Anja Dutschke, Shahrokh F. Shariat, Lucian Beer |
|---|---|
| Přispěvatelé: | Beer, Lucian [0000-0003-4388-7580], Baltzer, Pascal AT [0000-0002-3755-5398], Apollo - University of Cambridge Repository |
| Rok vydání: | 2019 |
| Předmět: |
Male
Prostate biopsy medicine.medical_treatment Biopsy Cancer Treatment Contrast Media Pathology and Laboratory Medicine 030218 nuclear medicine & medical imaging Diagnostic Radiology Prostate cancer 0302 clinical medicine Prostate Medicine and Health Sciences Prospective Studies Radiation treatment planning skin and connective tissue diseases Tomography Multidisciplinary medicine.diagnostic_test Prostate Cancer Radiology and Imaging Prostate Diseases Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Medicine Anatomy Research Article Clinical Oncology Image-Guided Biopsy Imaging Techniques Urology Science Perfusion Imaging Brachytherapy Radiation Therapy Neuroimaging Surgical and Invasive Medical Procedures Research and Analysis Methods Radiation Dosage Proof of Concept Study 03 medical and health sciences Exocrine Glands Signs and Symptoms Diagnostic Medicine medicine Humans Four-Dimensional Computed Tomography Aged Receiver operating characteristic business.industry Radiotherapy Planning Computer-Assisted Cancers and Neoplasms Biology and Life Sciences Prostatic Neoplasms Magnetic resonance imaging medicine.disease Computed Axial Tomography Genitourinary Tract Tumors Diffusion Magnetic Resonance Imaging Lesions Feasibility Studies Prostate Gland Biopsy Large-Core Needle Clinical Medicine Neoplasm Grading business Nuclear medicine Neuroscience Radiotherapy Image-Guided |
| Zdroj: | PLoS ONE, Vol 14, Iss 12, p e0225673 (2019) PLoS ONE |
| Popis: | PurposeAdvanced forms of prostate cancer (PCa) radiotherapy with either external beam therapy or brachytherapy delivery techniques aim for a focal boost and thus require accurate lesion localization and lesion segmentation for subsequent treatment planning. This study prospectively evaluated dynamic contrast-enhanced computed tomography (DCE-CT) for the detection of prostate cancer lesions in the peripheral zone (PZ) using qualitative and quantitative image analysis compared to multiparametric magnet resonance imaging (mpMRI) of the prostate.MethodsWith local ethics committee approval, 14 patients (mean age, 67 years; range, 57-78 years; PSA, mean 8.1 ng/ml; range, 3.5-26.0) underwent DCE-CT, as well as mpMRI of the prostate, including standard T2, diffusion-weighted imaging (DWI), and DCE-MRI sequences followed by transrectal in-bore MRI-guided prostate biopsy. Maximum intensity projections (MIP) and DCE-CT perfusion parameters (CTP) were compared between healthy and malignant tissue. Two radiologists independently rated image quality and the tumor lesion delineation quality of PCa using a five-point ordinal scale. MIP and CTP were compared using visual grading characteristics (VGC) and receiver operating characteristics (ROC)/area under the curve (AUC) analysis.ResultsThe PCa detection rate ranged between 57 to 79% for the two readers for DCE-CT and was 92% for DCE-MRI. DCE-CT perfusion parameters in PCa tissue in the PZ were significantly different compared to regular prostate tissue and benign lesions. Image quality and lesion visibility were comparable between DCE-CT and DCE-MRI (VGC: AUC 0.612 and 0.651, p>0.05).ConclusionOur preliminary results suggest that it is feasible to use DCE-CT for identification and visualization, and subsequent segmentation for focal radiotherapy approaches to PCa. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|