Role of calcium ions in the stimulatory actions of luteinizing hormone in isolated ovarian cells: Studies with divalent-cation ionophores
| Autor: | Patricia A. Klase, Johannes D. Veldhuis |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Swine Biophysics chemistry.chemical_element Stimulation Calcium Cycloheximide Biochemistry Divalent chemistry.chemical_compound Internal medicine medicine Animals Molecular Biology Calcimycin Progesterone chemistry.chemical_classification Granulosa Cells Ionophores Ionomycin Cell Biology Luteinizing Hormone In vitro Anti-Bacterial Agents Kinetics Endocrinology chemistry Female Luteinizing hormone Ethers |
| Zdroj: | Biochemical and Biophysical Research Communications. 104:603-610 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(82)90680-5 |
| Popis: | The divalent-cation ionophores A23187 and ionomycin exert dose-dependent suppressive effects on the stimulatory actions of luteinizing hormone in ovarian cells in vitro . Micromolar concentrations of both A23187 and ionomycin can inhibit the production of progesterone and the stimulation of ornithine decarboxylase activity. Inhibitory concentrations of these ionophores deplete total cell content of calcium, and also seem to suppress protein synthesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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