Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response
| Autor: | Matthew L. Wheeler, Baidong Hou, Martin F. Bachmann, Lili Kuzmich, Anthony L. DeFranco, Ming Ji, Linda M. Lee, Philippe Saudan, Robert L. Coffman, Gary Ott |
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| Rok vydání: | 2011 |
| Předmět: |
Immunology
B-cell receptor Antibodies Viral Article Mice 03 medical and health sciences 0302 clinical medicine Antigen medicine Animals Immunology and Allergy B cell 030304 developmental biology Mice Knockout B-Lymphocytes 0303 health sciences Toll-like receptor CD40 biology Models Immunological Germinal center Antiviral antibody Dendritic Cells Germinal Center Orthomyxoviridae Molecular biology Mice Inbred C57BL Infectious Diseases medicine.anatomical_structure Toll-Like Receptor 9 Myeloid Differentiation Factor 88 biology.protein Antibody Signal Transduction 030215 immunology |
| Zdroj: | Immunity. 34:375-384 |
| ISSN: | 1074-7613 |
| Popis: | Summary The contribution of Toll-like receptor (TLR) signaling to T cell-dependent (TD) antibody responses was assessed by using mice lacking the TLR signaling adaptor MyD88 in individual cell types. When a soluble TLR9 ligand was used as adjuvant for a protein antigen, MyD88 was required in dendritic cells but not in B cells to enhance the TD antibody response, regardless of the inherent immunogenicity of the antigen. In contrast, a TLR9 ligand contained within a virus-like particle substantially augmented the TD germinal center IgG antibody response, and this augmentation required B cell MyD88. The ability of B cells to discriminate between antigens based on the physical form of a TLR ligand probably reflects an adaptation to facilitate strong antiviral antibody responses. |
| Databáze: | OpenAIRE |
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