Pharmacological and neuroprotective profile of an essential oil derived from leaves of Aloysia citrodora Palau
| Autor: | S. Al-Olimat, Melanie-Jayne R. Howes, Paul L. Chazot, Abdelkader Ennaceur, Sawsan Abuhamdah, Rushdie Abuhamdah |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Antioxidant
medicine.medical_treatment Acyclic Monoterpenes Palau Aloysia citrodora Pharmaceutical Science Pharmacology Neuroprotection Antioxidants law.invention chemistry.chemical_compound Neuroblastoma Prosencephalon law Cell Line Tumor Cyclohexenes Verbenaceae medicine Oils Volatile Animals Plant Oils Mode of action Essential oil Polycyclic Sesquiterpenes Limonene Eucalyptol Aloysia biology sub_pharmacyandpharmacology Chemistry Terpenes Neurotoxicity Free Radical Scavengers biology.organism_classification medicine.disease Cyclohexanols Rats Plant Leaves Neuroprotective Agents Monoterpenes sub_neuropsychology Sesquiterpenes sub_biomedicalsciences |
| ISSN: | 2042-7158 |
| Popis: | Objectives The Jordanian ‘Melissa’, (Aloysia citrodora) has been poorly studied both pharmacologically and in the clinic. Essential oils (EO) derived from leaves of A. citrodora were obtained by hydrodistillation, analysed by gas chromatography-mass spectrometry (GC-MS) and were investigated for a range of neurobiological and pharmacological properties, as a basis for potential future use in drug discovery. Methods A selection of central nervous system (CNS) receptor-binding profiles was carried out. Antioxidant activity and ferrous iron-chelating assays were adopted, and the neuroprotective properties of A. citrodora EO assessed using hydrogen peroxide-induced and β-amyloid-induced neurotoxicity with the CAD (Cath.-a-differentiated) neuroblastoma cell line. Key findings The major chemical components detected in the A. citrodora EOs, derived from dried and fresh leaves, included limonene, geranial, neral, 1, 8-cineole, curcumene, spathulenol and caryophyllene oxide, respectively. A. citrodora leaf EO inhibited [3H] nicotine binding to well washed rat forebrain membranes, and increased iron-chelation in vitro. A. citrodora EO displays effective antioxidant, radical-scavenging activities and significant protective properties vs both hydrogen peroxide- and β-amyloid-induced neurotoxicity. Conclusions A . citrodora EO displays a range of pharmacological properties worthy of further investigation to isolate the compounds responsible for the observed neuroactivities, to further analyse their mode of action and determine their clinical potential in neurodegenerative diseases. |
| Databáze: | OpenAIRE |
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