Magnoflorine from Coptidis Rhizoma protects high density lipoprotein during oxidant stress
| Autor: | XinFeng Zhang, Byung Sun Min, KiHwan Bae, IkSoo Lee, Jae Sue Choi, Tran Manh Hung, Tran Minh Ngoc, Jong Pill Lee, MinKyun Na |
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| Rok vydání: | 2007 |
| Předmět: |
inorganic chemicals
Coptis chinensis Antioxidant Aporphines Thiobarbituric acid medicine.medical_treatment Amidines Pharmaceutical Science Pharmacology medicine.disease_cause Thiobarbituric Acid Reactive Substances Antioxidants Lipid peroxidation chemistry.chemical_compound Inhibitory Concentration 50 High-density lipoprotein medicine TBARS Humans Dose-Response Relationship Drug Molecular Structure Alkaloid General Medicine Oxidative Stress chemistry Biochemistry lipids (amino acids peptides and proteins) Lipid Peroxidation Lipoproteins HDL Magnoflorine Oxidative stress Copper Drugs Chinese Herbal |
| Zdroj: | Biologicalpharmaceutical bulletin. 30(6) |
| ISSN: | 0918-6158 |
| Popis: | The objective of the present study was to investigate the beneficial properties of magnoflorine, an alkaloid isolated from coptidis rhizoma, on protecting human high density lipoprotein (HDL) against lipid peroxidation. Magnoflorine exerts an inhibitory effect against Cu2+-induced lipid peroxidation of HDL, as showed by prolongation of lag time from 62 to 123 min at the concentration of 3.0 microM. It also inhibits the generation of thiobarbituric acid reactive substances (TBARS) in the dose-dependent manners with IC50 values of 2.3+/-0.2 microM and 6.2+/-0.5 microM since HDL oxidation mediated by either catalytic Cu2+ or thermo-labile radical initiator (AAPH), respectively. Separately, Cu2+ oxidized HDL lost the antioxidant action but the inclusion of magnoflorine/Cu2+ oxidized HDL can protect LDL oxidation according to increasing magnoflorine concentration. The results suggest that magnoflorine may have a role to play in preventing the HDL oxidation. |
| Databáze: | OpenAIRE |
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