Hypotensive and Prophylactic Effects of Angiotensin II Subtype 1 Receptor Antagonist, Irbesartan, in Stroke‐Prone Spontaneously Hypertensive Rats
| Autor: | Mikinori Torii, Toshitake Shimamura, Masatoshi Nakajima, Masao Masui |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Normal diet Systole Physiology medicine.drug_class Tetrazoles Blood Pressure Angiotensin II receptor antagonist Kidney urologic and male genital diseases Receptor Angiotensin Type 1 Irbesartan Diastole Heart Rate Rats Inbred SHR Internal medicine Renin–angiotensin system Internal Medicine medicine Animals Antihypertensive drug Antihypertensive Agents Dose-Response Relationship Drug urogenital system business.industry Biphenyl Compounds Body Weight Models Cardiovascular Brain Heart Organ Size General Medicine Receptor antagonist Immunohistochemistry Survival Analysis Angiotensin II Rats Stroke Disease Models Animal Endocrinology Blood pressure Hypertension business Angiotensin II Type 1 Receptor Blockers Biomarkers medicine.drug |
| Zdroj: | Clinical and Experimental Hypertension. 26:27-42 |
| ISSN: | 1525-6006 1064-1963 |
| Popis: | We determined the acute hypotensive effect of a single administration and the prophylactic effect of chronic treatment with Irbesartan, an angiotensin II receptor antagonist, on the development of end-organ damage in stroke-prone spontaneously hypertensive rats (SHRSP). The acute hypotensive effect was determined by a telemetrical method in SHRSP fed a normal diet. The prophylactic effect was examined by biochemical, histopathological and immunohistochemical methods in SHRSP fed a high-salt and low-protein diet. Irbesartan (3, 10, 30 and 100 mg/kg) reduced blood pressure in a dose-dependent manner without affecting heart rate. Irbesartan (3, 10 and 30 mg/kg) increased the survival rate in SHRSP fed a high-salt and low-protein diet. Furthermore, Irbesartan ameliorated the appearance of stroke symptoms in dose-dependent manner showing association with the prevention of microscopic lesions. Irbesartan ameliorated the increases in urinary protein excretion and N-acetyl-D-glucosamidase activity by preventing nephrosclerosis, as judged by microscopic observations, and ameliorated the increases in the expression of collagen IV and fibronectin in the kidney. These findings demonstrate that Irbesartan is a potent antihypertensive drug offering a protective effect on the development of hypertension-induced end-organ damages in SHRSP. Thus, Irbesartan is useful for the therapy of hypertension with end-organ damage. |
| Databáze: | OpenAIRE |
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