The effects of pentachlorophenol on intestinal solute absorption and fluid transfer in mice
| Autor: | David S. Madge |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Pentachlorophenol Time Factors Arginine Absorption (skin) In Vitro Techniques Mice chemistry.chemical_compound Body Water medicine Animals Histidine Pharmacology Chromatography Dose-Response Relationship Drug Biological Transport Histology In vitro Small intestine Glucose medicine.anatomical_structure Intestinal Absorption Liver chemistry Galactose Female Drug Contamination Chlorophenols |
| Zdroj: | General Pharmacology: The Vascular System. 12:169-175 |
| ISSN: | 0306-3623 |
| DOI: | 10.1016/0306-3623(81)90008-2 |
| Popis: | 1. 1. Using the mouse entire small intestine, in vitro absorption of D-glucose apparently decreased after 7 days following a single, oral dose (5 mg kg bodyweight) of technical pentachlorophenol (WP) but not purified pentachlorophenol (WN). Tissue solute accumulation fell slightly. The effects were related to both time and dosage. 2. 2. The absorption of d -galactose, l -arginine, and l -histidine, and solute tissue accumulation, remained unaltered using either WP or WN (5 mg kg bodyweight) compared with the untreated animals. 3. 3. Malabsorptive effects of d -glucose may have resulted from altered metabolism of the absorptive cells during the transfer process. 4. 4. Concomitant fluid transfer was unaffected using all solutes, as was the histology and fresh weight of the small intestine. 5. 5. These results are compared with similar investigations using various environmental pollutants and other work using technical and purified pentachlorophenol. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|