Effects of a casein hydrolysate versus intact casein on gastric emptying and amino acid responses
| Autor: | Victoria O’Sullivan, Pedapati S. C. Sri Harsha, Elaine Drummond, Katy Horner, Lorraine Brennan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty medicine.medical_treatment Casein Cmax Medicine (miscellaneous) 030209 endocrinology & metabolism Gastric emptying Hydrolysate 03 medical and health sciences 0302 clinical medicine Postprandial glycaemia Internal medicine medicine Humans Insulin Amino Acids Acetaminophen Aged chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics Cross-Over Studies Chemistry Caseins Middle Aged Postprandial Period Crossover study Amino acid Endocrinology Postprandial Glucose Gastric Emptying Female |
| Zdroj: | European journal of nutrition. 58(3) |
| ISSN: | 1436-6215 |
| Popis: | Purpose Milk proteins and/or their hydrolysates have been reported to have beneficial effects for improving postprandial glycaemia. Gastric emptying is a major determinant of postprandial glycaemia, yet limited studies have examined the effects of intact milk proteins compared to hydrolysates on gastric emptying. We investigated gastric emptying of a casein hydrolysate compared to intact casein. Methods Nine overweight and obese adults (mean ± SD age: 59.5 ± 6.5 years and BMI 28.4 ± 2.6 kg/m2) were studied in a randomised crossover design. Gastric emptying was assessed by paracetamol absorption test, with HPLC-MS being used for determining paracetamol and its primary metabolites in plasma. Glucose, insulin and amino acid responses were also assessed. Results Linear mixed model analysis showed no effect of treatment [F(1, 55) = 2.1, P = 0.16] or treatment × time interactions [F(6, 54) = 1.5, P = 0.21] for paracetamol concentrations. In addition, there were no significant differences between the intact casein and hydrolysate for any of the gastric emptying outcome measures (Cmax, AUC0–30min, AUC0–60min; AUC0–240min). However, insulin was increased in the early postprandial period (iAUC0–15min, iAUC0–30min; P |
| Databáze: | OpenAIRE |
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